The present invention provides therapeutic formulations for solutions of .DELTA..sup.9 -tetrahydrocannabinol (.DELTA..sup.9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of .DELTA..sup.9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.

Virginia Commonwealth University

.DELTA.9 Tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhaler

The present invention provides therapeutic formulations for solutions of .DELTA..sup.9 -tetrahydrocannabinol (.DELTA..sup.9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of .DELTA..sup.9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.

.DELTA.9 tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhalers and methods of use

The present invention relates to compressed tablets for peroral delivery of the cannabinoid .DELTA.9-tetrahydrocannabinol(THC). More particularly, the invention provides a compressed tablet having a tablet weight of 25-1000 mg, said tablet being composed of: compressed tablet containing delta 9-tetrahydrocannabinol, method for its manufacture and use of such tablet in oral treatment .cndot.30-90 wt % of a granulate; .cndot.10-70 wt % of lactose; and .cndot.0-30 wt % of other tablet excipients; wherein the granulate contains: a.2-5 wt % of .DELTA.9-tetrahydrocannabinol; b.2-20 wt % of sucrose fatty acid mono-ester; c.50-96 wt % of lactose; d.0.05-0.6 wt % of antioxidant; and e.0-25 wt % of other granulate excipients. The compressed tablets according to the invention can conveniently be used in the treatment of spasticity and pain caused by multiple sclerosis, neurophatic pain, chronic pain, behavioral disturbance by Alzheimer's disease, stroke, spinal cord injury, peripheral neuropathy, neurogenic pain, nociceptive pain and nausea. The invention further provides a method for the manufacture of the compressed tablets.

delta 9 thc/iiveldus

.DELTA.9 Tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhaler

.DELTA.9 tetrahydrocannabinol (.DELTA.9 THC) solution metered dose inhalers and methods of use

Compressed tablet containing .DELTA.9-tetrahydrocannabinol, method for its manufacture and use of such tablet in oral treatment

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