Pharmaceutical, cosmetic, nutraceutical and dietary compositions derived from Garcinia mangostana are rich in .gamma.-mangostin and other demethylated xanthones. These compositions exhibit potent antioxidative activity and reduce inflammation. These compositions may be used in a method of treating TNF-.alpha., and aP2 mediated disorders. The compositions are prepared by subjecting a hydroalcoholic extract of fruit pericarp (fruit hull) of Garcinia mangostana, wherein said hydroalcoholic extract comprises predominantly .alpha.-mangostin, to demethylation in the presence of a Lewis acid, an organic base and a catalyst.

Gokaraju; Ganga Raju

Gokaraju; Rama Raju

Golakoti; Trimurtulu

Chirravuri; Venkateswara Rao

gamma mangostin/garcinia mangostana

Nutraceutical composition from Garcinia mangostana

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