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indole/väsimus

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ArtiklidKliinilistes uuringutesPatendid
12 tulemused

Bichromophoric photochromes based on the opening and closing of a single oxazine ring.

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We have designed bichromophoric photochromes based on the photoinduced opening and thermal closing of a [1,3]oxazine ring. In particular, we have synthesized six compounds incorporating fused 3H-indole and 4-nitrophenoxy fragments and pendant biphenyl, styryl, biphenylvinyl, or stilbenylvinyl

Spironaphthoxazine switchable dyes for biological imaging.

Ainult registreeritud kasutajad saavad artikleid tõlkida
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Recent developments in super-resolution microscopy have significantly expanded the requirements for switchable dyes, leading to demand for specially designed molecular switches. We report the synthesis and characterization of a spironaphthoxazine photochromic switch (a derivative of palatinate

Metastatic small bowel neuroendocrine tumour with bilateral carcinoid heart disease.

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A 63-year-old woman was admitted with a year's history of exertional breathlessness, anxiety attacks, syncopal episodes, diarrhoea, fatigue, reduced appetite, 2 stones weight loss, and flushing affecting her face and trunk. Investigations revealed raised urine 5-hydroxy indole acetic acid (5-HIAA)

Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia.

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BACKGROUND Usual-type vulval intraepithelial neoplasia (uVIN) is a pre-cancerous condition of the vulval skin. Also known as high-grade VIN, VIN 2/3 or high-grade vulval squamous intraepithelial lesion (HSIL), uVIN is associated with high-risk subtype human papilloma virus (HPV) infection. The

Cellulose nanocrystals (CNC) as carriers for a spirooxazine dye and its effect on photochromic efficiency.

Ainult registreeritud kasutajad saavad artikleid tõlkida
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Nanocrystalline cellulose (CNC) as a renewable/sustainable material, has received much attention. Herein we studied CNC as carriers for a hydrophobic spirooxazine (SO)-based dye, 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3'-[3H]naphtha[2,1-b][1,4]oxazine], which may have potential applications in

Phase I trial of the thymidylate synthase inhibitor AG331 as a 5-day continuous infusion.

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AG331 (N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2, 6-diaminobenz-[c,d]-indole glucuronate) is a lipophilic thymidylate synthase inhibitor with activity in solid tumor models. On the basis of preclinical data supporting regimens of frequent drug administration, we performed a Phase I trial of

Effects of heteroaryl ring on the photochromism of asymmetrical diarylethenes containing a naphthalene group.

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Photochromic asymmetrical diarylethene derivatives 1o-4o bearing different benzo-five-membered heterocyclic rings were synthesized and characterized with single-crystal X-ray diffraction microscopy. The effects of heterocyclic ring on their properties including the photochromic behaviors in

Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependencea.

Ainult registreeritud kasutajad saavad artikleid tõlkida
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The potential for deriving new psychotherapeutic medications from natural sources has led to renewed interest in rain forest plants as a source of lead compounds for the development of antiaddiction medications. Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga (Apocynaceae

Medication development of ibogaine as a pharmacotherapy for drug dependence.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The potential for deriving new psychotherapeutic medications from natural sources has led to renewal interest in rain forest plants as a source of lead compounds for the development of antiaddiction medications. Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga (Apocynaceae

Interaction of a spirooxazine dye with latex and its photochromic efficiency on cellulosic paper.

Ainult registreeritud kasutajad saavad artikleid tõlkida
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Spirooxazine (SO) is a class of important photochromic dyes for many applications, such as anti-counterfeiting printing, reversible memory photo devices and optical switching elements in molecular electronics. Since these dyes are expensive, improving their coloration efficiency in response to photo
Chronic kidney disease (CKD) leads to increased skeletal muscle fatigue, weakness, and atrophy. Previous work has implicated mitochondria within the skeletal muscle as a mediator of muscle dysfunction in CKD; however, the mechanisms underlying mitochondrial dysfunction in CKD are not entirely known.

Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Ibogaine is an indole alkaloid found in the roots of Tabernanthe Iboga (Apocynaceae family), a rain forest shrub that is native to western Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and thirst, and in higher doses as a sacrament in religious rituals.
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