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Macrophage roles in the clearance of apoptotic cells and control of inflammation in the prostate gland after castration.

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BACKGROUND Androgen deprivation results in massive apoptosis in the prostate gland. Macrophages are actively engaged in phagocytosing epithelial cell corpses. However, it is unknown whether microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis (LAP) is involved and

(19)F NMR spectroscopic characterization of the interaction of niflumic acid with human serum albumin.

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The interaction of a non-steroidal anti-inflammatory drug, niflumic acid (NFA), with human serum albumin (HSA) has been investigated by (19)F nuclear magnetic resonance (NMR) spectroscopy. A (19)F NMR spectrum of NFA in a buffered (pH 7.4) solution of NaCl (0.1 mol L(-1)) contained a single sharp

Fanconi Anemia complementation group C protein in metabolic disorders.

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Given importance of 22-Fanconi Anemia (FA) proteins together to act in a signaling pathway in preventing deleterious clinical symptoms, e.g. severe bone marrow failure, congenital defects, an early onset of aging and cancer, studies on each FA protein become increasingly attractive. However, an

The role of various biomedical polymers concentration on the adhesion rate and viability of monocyte and monocyte derived macrophages.

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The relationship between various polymers used in surgical implantation and cellular response at that particular site has not been fully elucidated. The objective of this study was to investigate the effect of various biomedical polymers on the adherence and viability of monocyte and monocyte

Immobilization of L-asparaginase into a biocompatible poly(ethylene glycol)-albumin hydrogel: evaluation of performance in vivo.

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The L-asparaginase of Escherichia coli (ASNase) is currently used in combination with antineoplastic drugs to treat various lymphoblastic leukaemias. However, its use is limited by severe immunological reactions and the short serum half-life associated with the enzyme. Immobilization of ASNase into

Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway.

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Stress causes intestinal inflammation and barrier dysfunction. Corticotrophin-releasing factor (CRF)/CRF receptor (CRFR) signaling pathway has been shown to be important for stress-induced intestinal mucosal alteration. L-Asparagine (ASN) is a powerful stimulator of ornithine decarboxylase and cell

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