2% Doxycycline Cream in Generic Aquaphor will be applied topically twice during the study visit: first for 30 minutes, then for 6 hours duration. Will perform concurrent to Placebo Comparator

Generic Aquaphor will be applied topically twice during the study visit: first for 30 minutes, then for 6 hours duration. Will perform concurrent to Active Comparator.

Hives

2% Doxycline Cream in Generic Aquaphor or Generic Aquaphor will be applied topically twice during the study visit: first for 30 minutes, then for 6 hours duration.

2% Doxycycline Cream in Generic Aquaphor or Generic Aquaphor

SUNY Downstate Medical Center

Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline

Greatest diameter millimeters and orthogonal diameter millimeters, mean of both

Rauno Joks, MD

Chief Division of Allergy Immunology

State University of New York - Downstate Medical Center

This cross-sectional survey involves a single consecutive two day study visit.To assess the effect of topical doxycycline 2% emollient cream or control emollient on immediate hypersensitivity allergy skin tests responses, pruritus, and associated late phase skin swelling. We will use generic Aquaphor, a skin protectant, as the control emollient. The active ingredient in this cream is Petrolatum 42%. Inactive ingredients include ceresin, lanolin alcohol, microcrystalline wax, mineral oil, phenoxyethanol. Adults (18-75 yrs) with known respiratory (allergic rhinoconjunctivitis and/or asthma), and are allergen skin prick test (SPT) positive to common aeroallergens will, after 5 days of non-use of oral antihistamine therapy, undergo limited repeat SPT with the same allergens (up to 5 allergens per subject) with measurement of swelling, flare, and itch at 20 min, then after application of doxycycline cream or control emollient, at 30 min, 60 min, and 24 hrs post initial cream removal.

Nipple Wounds

Polymem

Lanolin

Laniado Hospital, The Betty Retter Mother & Baby Medical Center

Healing Nipple Wounds: Comparison Between 2 Treatment Modalities

Healing Nipple Wounds: Comparison Between 2 Treatment Modalities: Lanolin Ointmentnad Nursicare Therapeutic Breast Pads Among Postpartum Mothers Dealing With Sore Nipples

VAS scale will be used at several time points in order to assess the duration of pain reduction:
VAS scale ruler by the mother - if zero represents no pain and ten represents the worst pain imaginable, what number best describes the pain you have?
VAS scale ruler by the tester - If zero represents no pain and ten represents the worst pain imaginable, what number best describes the pain you think the mother has?

measurement of the percentage of wounds closed at each measure point. We will calculate the surface of the wound using an application for calculating area or with a disposable tape measure from paper.

This measurement will be filled in the questioner:
How do you feed your baby today?
Breastfeeding only
Breastfeeding combined with something else

This measurement will be filled in the questioner:
Were you satisfied with the use of Nursicare®/Lanolin as a treatment to your nipple pain?
Very satisfied
Satisfied
Moderately satisfied
Not satisfied
Not satisfied at all
It didn't affect me

This measurement will be filled in the questioner:
How did you find Nursicare® pads/Lanolin convenient to use?
Very convenient
Convenient
Not convenient
Not convenient at all

This measurement will be filled in the questioner:
Will you recommend your breastfeeding friends toy use Nursicare®/Lanolin in case they have nipple pain?
Definitely yes
Probably yes
I'm not sure
Probably not
Definitely not

This measurement will be filled in the questioner:
In case you have another wound in the future, will you use Nursicare®/Lanolin again to treat the pain?
Definitely yes
Probably yes
I'm not sure
Probably not
Definitely not

Dr. Meir Weisbrod

Director of Neonatal Department

Laniado Hospital

Dr. Jinna Weissman

Group A (current standard of care): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Hydrophor daily, starting at the onset of radiation therapy (RT) and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Hydrophor application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Hydrophor within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.

Group B (study target): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Medihoney daily, starting at the onset of RT and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Medihoney application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Medihoney within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.

Group A (current standard of care): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Hydrophor daily, starting at the onset of radiation therapy (RT) and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Hydrophor application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Hydrophor within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.
Hydrophor (Group A): •Rehydrates dry, chapped or chafed skin
•May be used alone as a skin lubricant or protectant

Hydrophor (Group A)

Group B (study target): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Medihoney daily, starting at the onset of RT and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Medihoney application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Medihoney within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.
MediHoney (Group B): It helps the body’s natural healing processes in three key ways which have been shown to have healing benefits:
Maintain a balanced environment for healing.
Aids in reducing dermatitis.
Reduce affected area pH.2-3

MediHoney (Group B)

Total

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

The aim of this study is to compare the effects of Medihoney and Hydrophor on radiation dermatitis reactions in a group of women undergoing radiation therapy for breast cancer. It is hoped that the outcome of this pilot study will provide evidence supporting the use of Medihoney in preventing and treating radiation dermatitis as well as sufficient preliminary data to expand this study to larger, federally funded research (R01) looking at the beneficial aspects of Medihoney across a spectrum of radiation dermatitis and mucositis in several disease settings.

Number of Participants Whom Received Medihoney Treatment and Were Analyzed Weekly for Skin Changes While Undergoing Radiation Therapy

Overall Study

Elizabeth Nichols, MD

Breast Cancer

Radiation Dermatitis

Rehydrates dry, chapped or chafed skin
May be used alone as a skin lubricant or protectant

It helps the body's natural healing processes in three key ways which have been shown to have healing benefits:
Maintain a balanced environment for healing.
Aids in reducing dermatitis.
Reduce affected area pH.2-3

lanolin/hypersensitivity

Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline

Healing Nipple Wounds: Comparison Between 2 Treatment Modalities

MediHoney for Radiation Dermatitis

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