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8 tulemused
Nitric oxide production is diminished in colonic circular muscle from acquired megacolon.
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OBJECTIVE
Nitric oxide modulates human colonic smooth muscle function. To determine whether nitric oxide production is altered in colon from acquired megacolon, we measured cholinergic nerve-mediated contractions in vitro before and after inhibition of nitric oxide synthase.
METHODS
Intramural
Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon.
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OBJECTIVE
Colonic inflammation may lead to motility disturbances, including severe atony. Nitric oxide is released by inflamed tissue and induces smooth muscle relaxation. The aim of this study was to analyze NO generation pathways in colonic tissue from patients who had ulcerative colitis with or
Ileal distention relaxes the canine colon: a model of megacolon?
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OBJECTIVE
Reflex relaxation is a mechanism whereby the colon can show short-term dilatation in the absence of mechanical obstruction. This study investigated the tonic response of the canine colon to ileal distention and its pharmacological control.
METHODS
In four dogs, the tone of the proximal
Analysis of the RET gene in subjects with sporadic Hirschsprung's disease.
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BACKGROUND
Hirschsprung's disease (HSCR), or aganglionic megacolon, is a hereditable disease of the enteric nervous system. It is an embryonic developmental disorder characterized by the absence of ganglion cells in the lower enteric plexus. Gut motility is compromised in HSCR, with consequent risk
Role of nitric oxide in the colon of patients with ulcerative colitis.
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The cause of impaired motility, such as diarrhea and toxic megacolon, in patients with ulcerative colitis (UC) is unknown. Nitric oxide (NO) has been shown to be a neurotransmitter in the nonadrenergic noncholinergic (NANC) inhibitory nerves in the human gut. To assess the physiologic significance
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease patients.
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BACKGROUND
Protein arginine methyltransferase 1 (PRMT1) catalyzes the majority of arginine methylation in cells and plays important roles in the differentiation and development of neurons. It is also implicated in the regulation of nitric oxide synthetase (NOS). Hirschsprung disease (HSCR) is
Clinical presentations and RET protooncogene mutations in seven multiple endocrine neoplasia type 2 kindreds.
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BACKGROUND
Multiple endocrine neoplasia type 2 (MEN 2) is a group of related autosomal dominant cancer syndromes caused by mutations in the RET protooncogene. A subset of familial Hirschsprung's disease, aganglionic megacolon, is also caused by mutations in this gene.
METHODS
The authors performed
Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease.
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Chagas disease, caused by Trypanosoma cruzi, represents an endemic among Latin America countries. The participation of free radicals, especially nitric oxide (NO), has been demonstrated in the pathophysiology of seropositive individuals with T. cruzi. In Chagas disease, increased NO contributes to
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- Maitsetaimede äratundmine pildi järgi
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- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
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