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FIELD OF THE INVENTION
The present invention is directed to the synthesis and identification of novobiocin analogues useful as a class of anticancer agents and/or neuroprotective agents. The compounds of the present invention act by inhibition of the Hsp90 protein-folding machinery.
DESCRIPTION OF
BACKGROUND OF THE INVENTION
The Hsp90 molecular chaperone has emerged as a promising target for the treatment of cancer. While most current therapies are directed at disrupting a single molecular function, Hsp90 is distinctive in its regulation of multiple oncogenic pathways. There are more than 100
BACKGROUND OF THE DISCLOSURE
The Hsp90 molecular chaperone has emerged as a promising target for the treatment of cancer. While most current therapies are directed at disrupting a single molecular function, Hsp90 is distinctive in its regulation of multiple oncogenic pathways. There are more than