Participants will consume one serving of the test food containing wild rice every day over 28 days.

Healthy Diet

Healthy

30 grams of wild rice in the form salad, snack bar and soup

wild rice

A Multidisciplinary Investigation of Cardiovascular Benefits of Wild Rice

This study is designed to investigate the effects of wild rice consumption on gut microbiome diversity and population in volunteer healthy young adults.

In this study, the investigators will establish whether changes in gut microbiome due to consumption of wild rice may result in altered macronutrient metabolism by studying plasma metabolomics.

In this study, plasma lipoprotein cholesterol concentrations will be estimated to assess the impact of wild rice consumption on the overall risk for atherosclerosis.

Mobil-O-Graph techniques will be used to measure endothelial cell function in the participants prior to consumption of wild rice and after 28 days of consumption of wild rice. This study will establish the effects of wild rice consumption on endothelial cell function.

Mohammed Moghadasian

Principal Investigator

University of Manitoba

after 4 weeks of lifestyle advice and changes, all subjects will receive for 8 weeks the administration of CARDIOVIS COLESTEROLO 3 mg, a nutraceutical compound containing containing red rice fermented with Monascus purpureus titrated with 3% monacolin K, hydrol mixture of olive fruit titrated with vitamin E, Coenzyme Q10 and polymethoxyflavones

Hypercholesterolemia

8-week administration of nutraceutical compound

nutraceutical

University Hospital of Ferrara

Nutraceutical in Cardiovascular Primary Prevention

Nutraceutical Compound to Optimize Cholesterol, Endothelial and Inflammatory Parameters in Subjects With Hypercholesterolemia and Low to Moderate Cardiovascular Risk: the NIRVANA Study

rate of apoptosis in human umbilical vein endothelial cells treated with subject's serum

NO generation in human umbilical vein endothelial cells treated with subject's serum

Gianluca Campo

Associate Professor, Interventional Cardiologist

Subjects that meet the inclusion/exclusion criteria and have provided informed consent will undergo a 4-week period of lifestyle advice and changes. If, after the 4 weeks, LDL values are confirmed above the established cutoffs, the subjects receive CARDIOVIS COLESTEROLO 3 mg for 8 weeks. After the 8-week treatment period, all biological paprameters will be reassessed. Finally, a last blood samples to assess a potential rebound effect after nutraceutical suspension is collected 4 weeks after the treatment stop.

oryza minuta/insult

A Multidisciplinary Investigation of Cardiovascular Benefits of Wild Rice

Nutraceutical in Cardiovascular Primary Prevention

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