Avocado based Mediterranean diet with intake of ½ portion of a Hass avocado per day, during 3 months.

Control-Group Diet consists of a low fat-high complex carbohydrate diet, during 3 months.

Stroke, Acute

Stroke, Ischemic

Mediterranean diet including 1/2 portion of Hass avocado per day, considering a minimum 35% of calories as fat (22% MUFA fat, 6% PUFA fat, and ±10% saturated fat), 15% proteins, and a maximum of 50% carbohydrates.

Avocado-Mediterranean Diet

A low fat-high complex carbohydrate diet, during 3 months.

Control-Group Diet

Clinica Alemana de Santiago

Effects of an Avocado Based meDiterranean Diet on Serum Lipids for Secondary Prevention After Ischemic StrokE Trial

Effects of an Avocado Based meDiterranean Diet on Serum Lipids for Secondary Prevention After Ischemic StrokE Trial (ADD-SPISE)

Low Density Lipoprotein (LDL) cholesterol level in mg/dL level at 3 months of the dietary intervention.

Total cholesterol level in mg/dL at 3 months of dietary intervention

High Density Lipoprotein (HDL) cholesterol level in mg/dL level at 3 months of the dietary intervention.

Triglycerides level in mg/dL level at 3 months of the dietary intervention.

Measure of waist diameter in centimeters and hip diameter in centimeters to report waist to hip ratio

Weight in kilograms and height in meters will be combined to report body mass index in kg/m^2

Frequency of major cardiovascular events (composed by acute myocardial infarction, stroke or vascular death).

ICAM (intercelular adhesion molecule) in ng/mL

VCAM (vascular cell adhesion molecule) in ng/mL

Measurement of plasma oleic acid levels compared to basal in a randomized sample of 35% of group randomized to avocado based mediterranean diet

Veronica Olavarria

Principal Investigator

Comisión Nacional de Investigación Científica y Tecnológica

Academic, open-label, blinded outcome assessment (PROBE design), clinical trial.

Study participants whose drink formulation contains no active ingredients but will appear and taste similar to the two other formulations. This will form the control formulation

Study participants' drink formulation will include Red Yeast Rice 600mg, Niacin 12.5mg, Phytosterol esters 650mg, L-Carnitine 150mg, vitamin C 500mg, and Co-Q-10 25mg.

The third formulation will be identical to the second, but without the Red Yeast Rice.

Hyperlipidemia

Each subject will be expected to consume a twice daily drink of approximately 4 ounces per serving taken with the morning and evening meals for a total of 8 weeks. Each bottle will contain two servings.

Placebo

Second Formulation

Third Formulation

Mitchell Karl, M.D. -- Cardiology

A Study Of Nutraceutical Drinks For Cholesterol (Evaluating Effectiveness and Tolerability)

A Multicenter Study Of Nutraceutical Drinks For Cholesterol (Evaluating Effectiveness and Tolerability)

The primary end point will be relative LDL and total cholesterol reductions, i.e., the placebo subtracted reduction in these parameters.

Secondary end points will include change from the control formulation with regard to HDL.

Secondary end points will include change from the control formulation with regard to CRP.

Secondary end points will include change from the control formulation with regard to triglyceride levels.

Dr. Mitchell Karl

Healthy Drink Discoveries, Inc.

Metabolic Syndrome

Obesity

Coronary Artery Disease

Ezetimibe

Partners Research

Effects of Ezetimibe Add-On to Statin Therapy on Adipokine Production in Obese and Metabolic Syndrome Patients With Atherosclerosis

Canadian Collaborative Research Network

Schering-Plough

Cardiovascular Diseases

Heart Diseases

Atherosclerosis

Coronary Disease

Cholesterol Homeostasis in Framingham Offspring Study

phytosterols and cholestanol (surrogate measures of cholesterol absorption) cholesterol precursors (surrogate measures of cholesterol synthetic rates)

phytosterol/insult

Effects of an Avocado Based meDiterranean Diet on Serum Lipids for Secondary Prevention After Ischemic StrokE Trial

A Study Of Nutraceutical Drinks For Cholesterol (Evaluating Effectiveness and Tolerability)

Effects of Ezetimibe Add-On to Statin Therapy on Adipokine Production in Obese and Metabolic Syndrome Patients With Atherosclerosis

Cholesterol Homeostasis in Framingham Offspring Study

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