The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo-older heteropolymeres, which comprise these nitrogenous compounds, d) amines of the type R.sup.1R.sup.2NR.sup.3, whereby R.sup.1, R.sup.2 and R.sup.3 are chosen independently from one another from the group consisting of H, C.sub.1-C.sub.5-alkyl groups and aryl groups, whereby R.sup.1, R.sup.2 and R.sup.3 are not H simultaneously, e) carboxylic acid amides, f) inorganic ammonium salts, g) ammonium groups containing inner salt compounds, h) antibiotica binding nucleic acid, i) compounds which bind in the small cavity of the DNA, and mixtures of two or more of these compounds. The invention provides In particular a method for the lysis of a biological sample, and methods for the stabilisation of biomolecules, a method for the decrease of inhibiting effects in a sample containing biomolecules and a differential masking method.

Qiagen GmbH

Method for the treatment of a sample containing biomolecules

The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo- oder heteropolymers, which comprise these nitrogenous compounds, d) amines of the type R.sup.1R.sup.2NR.sup.3, whereby R.sup.1, R.sup.2 and R.sup.3 are chosen independently from one another from the group consisting of H, C.sub.1-C.sub.5-alkyl groups and aryl groups, whereby R.sup.1, R.sup.2 and R.sup.3 are not H simultaneously, e) carboxylic acid amides, f) inorganic ammonium salts, g) ammonium groups containing inner salt compounds, h) antibiotica binding nucleic acid, i) compounds which bind in the small cavity of the DNA, and mixtures of two or more of these compounds. The invention provides in particular a method for the lysis of a biological sample, and methods for the stabilization of biomolecules, a method for the decrease of inhibiting effects in a sample containing biomolecules and a differential masking method.

The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo-oder heteropolymeres, which comprise these nitrogenous compounds, d) amines of the type R.sup.1R.sup.2NR.sup.3, whereby R.sup.1, R.sup.2 and R.sup.3 are chosen independently from one another from the group consisting of H, C.sub.1-C.sub.5-alkyl groups and aryl groups, whereby R.sup.1, R.sup.2 and R.sup.3 are not H simultaneously, e) carbonxylic acid amides, f) inorganic ammonium salts, g) ammonium groups containing inner salt compounds, h) antibiotica binding nucleic acid, i) compounds which bind in the small cavity of the DNA, and mixtures of two or more of these compounds. The invention provides in particular a method for the lysis of a biological sample, and methods for the stabilization of biomolecules, a method for the decrease of inhibiting effects in a sample containing biomolecules and a differential masking method.

Korfhage; Christian

Wilmer; Friederike

Loffert; Dirk

Himmelreich; Ralf

Fritz; Claudia

Rieske; Kathleen

This invention provides a single-phase aqueous solution of a zinc-polyamine complex which is stable and has a clear transparency. The aqueous solution can be incorporated as a component of an oral care product such as a mouthwash or toothpaste. The zinc-polyamine complex enhances the control of oral malodor, plaque, calculus and gingivitis in dental applications, and decreases the astringency and metallic taste which is characteristic of zinc ions in an oral cavity.

Church &amp; Dwight Co., Inc.

Aqueous zinc-polyamide complex solution

The invention describes the modification of polyamine-based materials to form polyguanidine compounds that are useful for their antimicrobial, anticaries, and muccoadhesive properties. The present invention also relates to methods for preventing or treating periodontal disease and caries which include delivering a therapeutically effective amount of an oral composition containing a polyguanidine compound into an oral cavity.

polyamine/kaaries

Method for the treatment of a sample containing biomolecules

Method for the treatment of a sample containing biomolecules

Method for the treatment of a sample containing biomolecules

Aqueous zinc-polyamide complex solution

Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof

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