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polyene/vähk

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Leht 1 alates 84 tulemused
Chemoradiotherapy in inoperable non-small cell lung cancer (NSCLC) is standard, but accompanied by undesirable adverse effects such as radiation pneumonitis. Polyene phosphatidylcholine (PPC) is a hepatoprotective agent and can be used as nutritional adjuvant to chemotherapy. We aimed to investigate
In the present work, a series of conjugates of amino acids with all-trans-retinoic acid (ATRA) and shorter polyene chain analogues were rationally designed, synthesized by coupling the succinimidyl active esters of the acidic retinoids with appropriately protected amino acids or peptides followed by

Effect of Chemically Transformed Macrocyclic Polyene Antibiotics on Tumor Cells.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Comparative analysis of the effects of chemically transformed polyene antibiotics pimaricin, nystatin, lucensomycin, amphotericin B, and levorin on biological objects in vivo and in vitro revealed the greatest biological activity of original amphotericin B and levorin with its derivatives. The study

New capoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Capoamycin-type antibiotics (2-5) and polyene acids (6, 7) were isolated from marine Streptomyces fradiae strain PTZ0025. Their structures were established by extensive nuclear magnetic resonance (NMR) and high resolution electron spray ionization mass spectroscopy (HRESIMS) analyses and chemical

Cytotoxic activity of polyacetylenes and polyenes isolated from roots of Echinacea pallida.

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Logi sisse
OBJECTIVE The n-hexane extracts of the roots of three medicinally used Echinacea species exhibited cytotoxic activity on human cancer cell lines, with Echinacea pallida found to be the most cytotoxic. Acetylenes are present in E. pallida lipophilic extracts but essentially absent in extracts from
The genus Echinacea (Asteraceae) includes species traditionally used in phytotherapy. Among them, Echinacea pallida (Nutt.) Nutt. root extracts are characterized by a representative antiproliferative activity, due to the presence of acetylenic compounds. In this study, supercritical fluid extraction
A combinatorial library of polyenes, based on (-)-stipiamide, has been constructed and evaluated for the discovery of new multidrug resistance reversal agents. A palladium coupling was used to react each individual vinyl iodide with a mixture of the seven acetylenes at near 1:1 stoichiometry. The

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND Systemic fungal infection is considered to be an important cause of morbidity and mortality in cancer patients, particularly those with neutropenia. Antifungal drugs are often given prophylactically, or to patients with persistent fever. OBJECTIVE To compare the effect of fluconazole and

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND Systemic fungal infection is considered to be an important cause of morbidity and mortality in cancer patients, particularly those with neutropenia. Antifungal drugs are often given prophylactically, or empirically to patients with persistent fever. OBJECTIVE To compare the effect of

Amphotericin B vs fluconazole for controlling fungal infections in neutropenic cancer patients.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND Systemic fungal infection is considered to be an important cause of morbidity and mortality in cancer patients, particularly those with neutropenia. Antifungal drugs are often given prophylactically, or to patients with persistent fever. OBJECTIVE To compare the effect of fluconazole and
The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early

Trichosporon inkin Esophagitis: An Uncommon Disease in a Patient with Pulmonary Cancer.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Trichosporon species are usually opportunistic pathogens. Here, we present a case of esophagitis caused by T. inkin in a 54-year-old woman with pulmonary cancer and severe neutropenia in whom the susceptibility profile of the isolate against azoles and polyenes was verified. The patient was

Infections due to resistant Candida species in patients with cancer who are receiving chemotherapy.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The apparent increase in the prevalence of candidal infections among patients with cancer and the changes in the spectrum of Candida pathogens infecting these patients are associated with a number of factors. Selection of less-susceptible organisms occurs because antibacterial and antifungal agents

The effect of amphotericin B on the survival of brain-tumor-bearing mice treated with CCNU.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The membrane-active polyene, amphotericin B (AMB) has been shown to enhance or potentiate the effects of various chemotherapeutic agents against tumor cells in tissue culture. Because of the need to increase the efficacy of the nitrosoureas in brain-tumor chemotherapy, we have studied the effect of

Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Tumour necrosis factor (TNF)-alpha inhibitors are widely used agents in the treatment of a variety of inflammatory and granulomatous diseases. It has long been appreciated that these agents confer an increased risk of tuberculosis; however, more recently it has been recognized that patients being
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