30 mL tart cherry concentrate (CherryActive, UK) diluted with 220 mL of water once per day (250 mL total volume per day). According to available manufacturers data, this is equivalent to consuming 90-100 fresh cherries per day.

Matched for sensory characteristics and energy (with the addition of glucose).
once per day (250 mL total volume per day)

Gout Flare

Gout Attack

30 mL tart cherry juice concentrate (CherryActive, UK), diluted with water to 250 mL. This is consumed daily by participants, with breakfast, for 12 months.

Tart cherry juice

Consumed daily by participants, with breakfast, for 12 months.

Fruit-flavoured placebo drink

Food and Nutrition Group, Sheffield Hallam University

The Effect of Tart Cherry Juice on Risk of Gout Attacks

The Effect of Tart Cherry Juice on Risk of Gout Attacks: a Randomised Controlled Trial

Difference in gout flare frequency in tart cherry juice group versus placebo group from baseline to 12 months. Recorded as number per month.

Difference in gout flare intensity in tart cherry juice group versus placebo group from baseline to 12 months. Using a 0-10 Likert pain scale. The scale measures the pain of any gout flare. The possible score ranges from 0 for no pain through to 10 for worst pain imaginable. Change in pain scores between treatment and placebo groups will be compared throughout the duration of the intervention.

Difference in serum urate in tart cherry juice group versus placebo group from baseline to 12 months.

Difference in fractional excretion of uric acid in tart cherry juice group versus placebo group from baseline to 12 months. Measured from 24 hour urine sample.

Difference in inflammatory markers (c reactive protein (CRP), inter leukin-6 (IL-6) and tumour necrosis factor- alpha (TNF-alpha)) in tart cherry juice group versus placebo group from baseline to 12 months. Measured using an enzyme-linked immunosorbent assay (ELISA).

Difference in markers of oxidative stress in tart cherry juice group versus placebo group from baseline to 12 months. Measured using single-cell electrophoresis 'comet assay' as 8-oxo-dg levels in lymphocytes.

Difference in antioxidant status in tart cherry juice group versus placebo group from baseline to 12 months. Measured using single-cell electrophoresis 'comet assay' as resistance of DNA lymphocyte to H202-induced DNA strand breaks.

Difference in brachial and central blood pressure in tart cherry juice group versus placebo group from baseline to 12 months. Measured using a Vicorder.

Difference in arterial stiffness in tart cherry juice group versus placebo group from baseline to 12 months.

Difference in total cholesterol, HDL cholesterol, LDL cholesterol and triacylglycerides) in tart cherry juice group versus placebo group from baseline to 12 months.

Height and weight will be combined to report BMI in kg/m^2. Difference in BMI in tart cherry juice group versus placebo group from baseline to 12 months.

4 day diet diaries will be used to assess any changes in habitual diet as a result of, or over the course of, the study.

4 day physical activity logs will be used to assess any changes in habitual activity levels as a result of, or over the course of, the study.

Tony Lynn

Principal Lecturer (Food and Nutrition Group)

Sheffield Hallam University

Cherry Research Committee

Participants will be randomly allocated to consume either tart cherry juice or a fruit-flavoured placebo drink (matched as closely as possible for energy and sensory characteristics) daily for 12 months.

Prunus domestica extract capsules, 100mg, BD

Prunus domestica extract

Phytotherapeutic agents in the treatment of benign prostatic hyperplasia

Department of Urology, King George's Medical University, Lucknow, UP, India

Efficacy of Prunus Domestica Extract in BPH

EFFICACY EVALUATION OF PRUNUS DOMESTICA EXTRACT ON BENIGN PROSTATE HYPERPLASIA (BPH): An Add on Study

Chemical Resources

Cardiovascular Disease

Coronary Heart Disease

Aging

Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome

Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults:Interactions With Genotype and Proteome

National Institute of Nursing Research (NINR)

subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder

prunus amygdalus/seenevastane

The Effect of Tart Cherry Juice on Risk of Gout Attacks

Efficacy of Prunus Domestica Extract in BPH

Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome

Pilot Study on the Tolerability of Dietary Dried Plum

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