8 weeks of 25 g/day of milled chia supplemented-isocaloric diet

Non-Alcoholic Fatty Liver Disease

Dietary Modification

8 weeks of an isocaloric diet supplemented with 25 g/day of milled chia

Milled chia seeds

Chia Supplementation and Non Alcoholic Fatty Liver Disease

Effect of a Chia Supplemented Diet (Salvia Hispanica) on the Cardiometabolic Risk Profile in Patients With NAFLD (Non Alcoholic Fatty Liver Disease)

To assess the effect of 25 g/day of milled chia in 25 patients with NAFLD.Improvement of LSAI (liver spleen attenuation index) measured by computed tomography In a single-arm experimental design study

Increase in Alpha linolenic acid with chia supplemented diet. Measured by gas chromatography.

Improvement of lipid parameters (total colesterol, LDL-C, triglycerides, HDL-C) including free fatty acids

Aida Medina Urrutia

Medical sience investigator

Instituto Nacional de Cardiologia Ignacio Chavez

10% of a participants total kcal estimated needs given in chia seeds everyday for 8 weeks.

Habitual diet with avoidance of high fiber and high omega-3 fatty acid foods.

Obesity

Eating Behavior

Mood

Glucose

Chia seed added-10% of kcals and a no-chia control diet. 10% will be calculated using the following formula: Harris-Benedict equation multiplied by the activity factor of 1.2, 1.375, and 1.55 depending on each participant's activity level based on the information provided on the initial screening form.

Chia Seeds- Salvia Hispanica

California State Polytechnic University, Pomona

The Effects of Chia on Overweight/Obese Women

Effects of Chia Seed Consumption on Body Composition, Blood Pressure, Blood Glucose, Satiety, Diet Displacement, Joint Pain, Mood and Serotonin Levels in Young, Healthy, Overweight/Obese Females

12-hour fasting plasma glucose levels will be assessed using a glucometer

waist circumference will be measured for each participant

9, 3-day diet journals will be collected using a paper method

2-hour fasting plasma glucose levels will be assessed using a glucometer

waist will be measured for each participant

Hip Circumference will be measured for each participant

Blood pressure will be taken using an automatic blood pressure machine

Joint pain will be assessed using The WOMAC (Western Ontario and McMaster Universities) Index of Osteoarthritis

INTERNATIONAL PHYSICAL ACTIVITY QUESTIONNAIRE (August 2002) SHORT LAST 7 DAYS SELF-ADMINISTERED FORMAT

Measuring sleep quality using the Pittsburgh Sleep Quality Index

3, 3-day diet journals will be collected using a paper method

Desiree Vera

Graduate Student, Human Nutrition and Food Science

Human subjects- females (18-45 y.o.) with a BMI greater than or equal to 26.

54 grams of hulled sesame seeds, consumed in 2 daily 27 gram portions, and 30 grams of soybean oil per day

60 grams of hulled hemp seeds,consumed in 2 daily 30 gram portions, and 30 grams of hemp oil per day

Overweight

Control

Hemp foods

Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba

FREE Living Hulled HEMP Seed and Oil Trial

Total lipids will be extracted from each fraction (whole plasma, RBC) and will be evaluated for its fatty acid composition using gas-chromatography linked with flame ionization detector

TC, HDL-C and TG in serum, will be determined by automated methods in duplicate on an auto-analyzer (VITROS 350). LDL-C concentrations will be calculated using the Friedewald equation.

Measurement of inflammatory biomarker such as CRP, IL-6 and TNF-α and cell adhesion molecules such as e-selectin, p-selectin, s-ICAM and s-VCAM, will be measured in multiplex on a Meso Scale Discovery platform.

Blood pressure will be measure in conjunction with pulse wave velocity (PWV) and augmentation index (AI) to assess arterial stiffness using a Mobil-O-Graph, in triplicate.

Measurement of fasting glucose using an auto-analyzer, and insulin by radioimmunoassay, to investigate the impact of hemp product consumption on glucose metabolism and insulin sensitivity.

Using a Dual Energy X-Ray Absorptiometry machine to analyze body composition, including measuring visceral adiposity

The activity monitors will measure the participants' physical activity levels, steps taken, and the different amounts of time spent at different activity levels.

Dr. Peter J. H. Jones

Canada Research Chair in Functional Foods and Nutrition, Director of the Richardson Centre for Functional Foods and Nutraceuticals

University of Manitoba

White bread with 7.32 grams Salba hispanica

White bread with 15.58 grams Salba hispanica

White bread with 24 grams Salba hispanica

Rice Milk with 7.32 grams Salba hispanica

Rice Milk with 15.58 grams Salba hispanica

Post Prandial Blood Glucose

About 100g of white bread consisting of 50g of available carbohydrates, served with 250mL water

White Bread

About 100g of white bread consisting of 50g of available carbohydrates and 7.32g Salvia hispanica, served with 250mL water

White bread with added 7.32g Salvia hispanica

White bread with added 15.58g Salvia hispanica

About 100g of white bread consisting of 50g of available carbohydrates and 24g Salvia hispanica, served with 250mL water

White bread with added Salvia hispanica

Rice milk containing 50g of available carbohydrates

Rice milk

Rice milk containing 50g of available carbohydrates with 7.32g added Salvia hispanica

Enriched rice milk containing 7.32g Salvia hispanica

Rice milk containing 50g of available carbohydrates with 15.58g added Salvia hispanica

Enriched rice milk containing 15.58g Salvia hispanica

Rice milk containing 50g of available carbohydrates with 24g added Salvia hispanica

salvia carduacea/rasvumus

Chia Supplementation and Non Alcoholic Fatty Liver Disease

The Effects of Chia on Overweight/Obese Women

FREE Living Hulled HEMP Seed and Oil Trial

The Effects of Salvia Hispanica-Enriched Foods on Glycemic and Insulinemic Responses and Subjective Satiety

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