systematic research of digestive symptoms in patients with SGSp with Global symptom score (GSS) questionary.

Sjogren's Syndrome

Digestive System Abnormalities

systematic research of digestive symptoms in patients with SGSp with Global symptom score (GSS) questionary, which allowed to grades severity of 10 digestive symptoms (absent, mild, moderate, or severe), asthenia and fever.

Global symptom score (GSS) questionary

University Hospital, Limoges

Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome

Measure the prevalence of functional digestive symptoms during SGSp globally and as a function of the duration of the disease

Measure the prevalence of each GSS symptom and its severity during the pSGS, globally and depending on the duration of disease

Determine the possible association between the presence of digestive disorders (each symptom) and SGSp activity, painfulness experienced by the patient, anti-SSA antibody, and / or SSB

Determine the possible association between the presence of digestive symptoms, the existence of a sicca syndrome at the time of screening, neurological involvement, pulmonary involvement, parotiditis, depressive disorders, fibromyalgia, hypergammaglobulinemia

Describe the digestive disorders discovered by the digestive explorations generated by the existence of digestive symptoms, in accordance with the usual rules of good practice

Global symptom score (GSS) questionary . This questionnaire has the advantage of grading the severity of These digestive symptoms.

Granulomatosis With Polyangiitis

Microscopic Polyangiitis

Wegener's

Rare Diseases Clinical Research Consortium

Boston University School of Medicine

Mayo Clinic

Cleveland Clinic Foundation

University of Pennsylvania

University of Pittsburgh

University of Utah

St. Joseph's Healthcare

Mount Sinai Hospital

Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis

Determining Disease Activity Biomarkers in Individuals With Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis

Peter Merkel

Professor

Office of Rare Diseases (ORD)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Rare Diseases Clinical Research Network

Autologous Stem Cell Transplant will be performed on eligible patients

Allogeneic Stem Cell Transplant will be performed on eligible patients

Autologous Stem Cell Transplant will be performed on eligible patients
Autologous Stem Cell Transplant: Autologous Hematopoietic Stem Cell Transplant will be performed after conditioning

Autologous Stem Cell Transplant

Allogeneic Stem Cell Transplant will be performed on eligible patients
Allogeneic Stem Cell Transplant: Allogeneic Stem Cell Transplant will be performed after conditioning

Allogeneic Stem Cell Transplant

Total

Sex: Female, Male

Region of Enrollment

Survival

Overall Study

Dr Richard Burt

Vasculitis

Autologous Hematopoietic Stem Cell Transplant will be performed after conditioning

Allogeneic Stem Cell Transplant will be performed after conditioning

Cyclophosphamide

A rabbit polyclonal antibody to lymphocyte

ATG (rabbit)

G-CSF

Humanized monoclonal antibody against CD52 antigen

Campath-1h

Fludarabine

Tacrolimus

Mesna is a drug used to protect the bladder from the effects of the chemotherapy drugs

Mesna

Northwestern University, Feinberg School of Medicine

Hematopoietic Stem Cell Support in Vasculitis

High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet's Disease, and Sjogren's Syndrome

systemic vasculitis/palavik

Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome

Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis

Hematopoietic Stem Cell Support in Vasculitis

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