The method of detecting thalassemia by optical analysis of blood components is a spectral detection method that is based on the fluorescence spectra of a set of biomolecules, including tyrosine, tryptophan, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide, which are all found in blood plasma, and porphyrin, which is found in red blood cells (RBCs). Measured ratios of intensity maxima between tryptophan and nicotinamide adenine dinucleotide, flavin adenine dinucleotide and nicotinamide adenine dinucleotide, tyrosine and tryptophan, and the normal form of porphyrin and the basic form of porphyrin may each be used, alone or in combination, to diagnose a patient as suffering from thalassemia.

Salhi; Mohamad Saleh Al

Masilamani; Vadivel

Algahtani; Farjah Hassan

KING SAUD UNIVERSITY

Method of detecting thalassemia by optical analysis of blood components

Peptide sequences and analogs thereof based on amino acid motifs in band 3 which are effective in reducing the adhesiveness of pathologically adhesive red blood cells. One class of peptide sequences are characterized by the sequence motif Z.sup.1 xKxxx+ (SEQ ID NO:45), wherein Z.sup.1 is selected from the group consisting of tyrosine, phenylalanine and alanine; x is an unobstructive residue and + is a positively charged residue (e.g., K or P--H). These peptides are used to reduce adhesiveness in the treatment of sickle cell disease, thalassemia and diabetes. A second class of peptide sequences are characterized by the sequence motif Z.sup.2 Z.sup.3 Z.sup.2 -x-xxxx- (SEQ ID NO:46), wherein Z.sup.2 represents a hydrophobic residue, x is an unobstructive residue and - is a negatively charged residue. These peptides can be used to reduce adhesiveness in the treatment of malria, sickle cell disease, thalassemia and diabetes.

thalassemia/tyrosine

Method of detecting thalassemia by optical analysis of blood components

Compositions and methods for reducing adhesiveness of defective red blood cells

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