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topotecan/kaaries

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8 tulemused

Chronic Convection Enhanced Delivery of Topotecan

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Malignant gliomas are among the most pernicious of human tumors - locally invasive and universally recurrent, with recurrence usually occurring within two centimeters of the original resection cavity. Although numerous chemotherapeutic drugs demonstrate significant anti-tumor activity in preclinical

Topotecan in Glioma Undergoing A Clinically-Indicated Surgical Resection

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Primary Objectives - To investigate by magnetic resonance (MR) imaging the spatial and temporal distribution of topotecan in tumor-infiltrated brain administered by convection-enhanced delivery (CED) in patients with recurrent/progressive WHO grade III or IV (high grade) glioma (HGG) who have failed
PRIMARY OBJECTIVE: I. To estimate the progression-free survival (PFS) hazard ratio of trametinib compared to that of "commercially available therapies" consisting of one of five commercially available agents in women with recurrent low-grade serous carcinoma of the ovary or peritoneum previously
OBJECTIVES: - To determine the maximum tolerated dose of topotecan hydrochloride combined with high-dose cyclophosphamide and carboplatin in the setting of autologous peripheral blood stem cell transplantation for relapsed, recurrent, or persistent ovarian epithelial or primary peritoneal cavity
OBJECTIVES: Primary - Determine the efficacy of lapatinib ditosylate and topotecan hydrochloride, in terms of response, in patients with platinum-resistant or refractory ovarian epithelial or primary peritoneal cavity carcinoma. Secondary - Determine the overall survival time in patients treated

Topotecan in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVES: Primary - Determine the maximum tolerated dose of weekly topotecan in patients with progressive or recurrent ovarian epithelial, fallopian tube, or primary peritoneal cavity cancer and a poor performance status. Secondary - Estimate the response rate of women with poor performance status
OBJECTIVES: Primary - Determine the nature and degree of toxicity of gemcitabine and topotecan in patients with recurrent or persistent platinum-refractory ovarian, fallopian tube, or primary peritoneal cavity cancer. - Determine the response rate in patients treated with this regimen. - Determine
OBJECTIVES: - Determine the maximum tolerated dose and recommended phase II dose of UCN-01 and topotecan in patients with recurrent ovarian epithelial, fallopian tube, or primary peritoneal cavity cancer. - Determine the safety and tolerability of this regimen in these patients. - Determine the
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