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13 tulemused
Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The therapeutic effects of intraperitoneal topotecan, a water-soluble camptothecin analogue, were investigated in two models of human ovarian carcinoma xenografted intraperitoneally into nude mice: the IGROV-1 tumour, which originated from an untreated patient, and the A2780 tumour, selected for
A phase I and pharmacokinetic study of intraperitoneal topotecan.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE
To evaluate the feasibility and pharmacology of intraperitoneal (IP) topotecan.
METHODS
Fifteen patients with recurrent ovarian cancer in a phase I trial were treated with escalating IP topotecan doses (5-30 mg/m(2)) for pharmacokinetic analysis.
RESULTS
Dose limiting toxicity (DLT) was
Phase I and pharmacokinetic study of intraperitoneal topotecan.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE
To determine the maximum tolerated dose and pharmacokinetics of topotecan when administered by the intraperitoneal route.
METHODS
A dose-escalating Phase I trial was conducted in which fifteen % of the total dose was given as an intraperitoneal bolus in two litres of D5W and the remainder
Supramolecular host-inhibited excited-state proton transfer and fluorescence switching of the anti-cancer drug, topotecan.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The effect of cucurbit[7]uril (CB[7]) nano-caging on the photophysical properties, particularly excited-state proton transfer (ESPT) reaction, of an eminent anti-cancer drug, topotecan (TPT), is demonstrated through steady-state and time-resolved fluorescence measurements. TPT in water (pH 6) exists
Topophore C: a liposomal nanoparticle formulation of topotecan for treatment of ovarian cancer.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
We have recently developed a liposomal nanoparticle (LNP) formulation of irinotecan based on loading method that involves formation of a complex between copper and the water soluble camptothecin. The loading methodology developed for irinotecan was evaluated to develop a LNP topotecan formulation
Surgical treatment of an isolated omental cervical cancer recurrence: report of a case and review of the literature.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE
Recurrent cervical cancer has traditionally been associated with a dismal prognosis. Historically, patients who developed distant metastases from cervical cancer were not considered eligible for surgical resection; only palliative treatment options are available, generally consisting of
Pressurized IntraPeritoneal Aerosol Chemotherapy vs. intravenous chemotherapy for unresectable peritoneal metastases secondary to platinum resistant ovarian cancer - study protocol for a randomized control trial.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Long-term survival after intraperitoneal chemotherapy with paclitaxel-cisplatin for recurrent primary peritoneal cancer resistant to multiple lines of intravenous chemotherapy.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The long-term survival of heavily pretreated patients with primary peritoneal cancer (PPC) is uncommon. Here, we report on a patient with PPC refractory to multiple lines of intravenous chemotherapy, namely, a combined regimen of paclitaxel and carboplatin, and single regimens of topotecan,
On the encapsulation and assembly of anticancer drugs in a cooperative fashion.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
In this study, we report the remarkable recognition and assembly characteristics of D3h symmetric basket 16- containing two adjoining and nonpolar cavities with six biocompatible GABA residues at their northern and southern termini. From the results of
Polysaccharide-gold nanocluster supramolecular conjugates as a versatile platform for the targeted delivery of anticancer drugs.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Through the high affinity of the β-cyclodextrin (β-CD) cavity for adamantane moieties, novel polysaccharide-gold nanocluster supramolecular conjugates (HACD-AuNPs) were successfully constructed from gold nanoparticles (AuNPs) bearing adamantane moieties and cyclodextrin-grafted hyaluronic acid
Binding Performance of Human Intravenous Immunoglobulin and 20(S)-7-Ethylcamptothecin.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
A previous study showed that intravenous immunoglobulin (IVIG) could preserve higher levels of biologically active lactone moieties of topotecan, 7-ethyl-10-hydroxycamptothecin (SN-38) and 10-hydroxycamptothecin at physiological pH 7.40. As one of camptothecin analogues (CPTs), the interaction of
AAV-mediated persistent bevacizumab therapy suppresses tumor growth of ovarian cancer.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND
Anti-angiogenesis therapies such as bevacizumab, the monoclonal antibody to vascular endothelial growth factor (VEGF), have been used against ovarian cancer, but transient and low peritoneal drug levels are likely a factor in treatment failure. We hypothesized that a single administration
Selective binding and controlled release of anticancer drugs by polyanionic cyclodextrins.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The binding stoichiometry, binding constants, and inclusion mode of some water-soluble negatively charged cyclodextrin derivatives, i.e. heptakis-[6-deoxy-6-(3-sulfanylpropanoic acid)]-β-cyclodextrin(H1), heptakis-[6-deoxy-6-(2-sulfanylacetic acid)]-β-cyclodextrin(H2),
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
- Töötab 55 keeles
- Taimsed ravimid, mida toetab teadus
- Maitsetaimede äratundmine pildi järgi
- Interaktiivne GPS-kaart - märgistage ürdid asukohas (varsti)
- Lugege oma otsinguga seotud teaduspublikatsioone
- Otsige ravimtaimi nende mõju järgi
- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
Sisestage sümptom või haigus ja lugege ravimtaimede kohta, mis võivad aidata, tippige ürdi ja vaadake haigusi ja sümptomeid, mille vastu seda kasutatakse.
* Kogu teave põhineb avaldatud teaduslikel uuringutel
