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topotecan/turse

Link salvestatakse lõikelauale
13 tulemused
OBJECTIVE To determine intravitreal and plasma concentrations and retinal toxicity after transcorneal intravitreal injection of 1 μg and 2 μg of topotecan (Hycamtin). METHODS Twelve healthy albino rabbits were included in this in vivo experiment. Six anesthetized albino rabbits received a single

Recurrent encephaloclastic cyst induced by intraventricular topotecan.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE To report two rare cases of encephaloclastic cyst induced by intraventricular topotecan. To share our experience in diagnosing and treating this rare disease. BACKGROUND Ommaya reservoirs provide fast access and reliable drug delivery to cerebral spinal fluid. They are routinely utilized

A phase I study of periocular topotecan in children with intraocular retinoblastoma.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE To identify the maximum tolerated dose and dose-limiting toxicity of periocular topotecan in patients with relapsed or resistant intraocular retinoblastoma who are facing imminent enucleation. METHODS For this phase I study, a starting dose of 0.5 mg of periocular topotecan administered
OBJECTIVE To examine the tolerability and antitumor activity of trebananib plus pegylated liposomal doxorubicin (PLD) or topotecan in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer. METHODS In this open-label phase 1b study, patients received trebananib 10 mg/kg or 15

Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Convection-enhanced delivery (CED) for the treatment of malignant gliomas is a technique that can deliver chemotherapeutic agents directly into the tumor and the surrounding interstitium through sustained, low-grade positive-pressure infusion. This allows for high local concentrations of drug within
BACKGROUND Treatment of eyes with retinoblastoma failing systemic chemoreduction and external beam radiotherapy is seldom efficacious. This study compares the efficacy and toxicity of intra-arterial ophthalmic artery chemotherapy (IAO) to our historical cohort of sequential periocular and systemic

Chemotherapy-induced posterior reversible encephalopathy syndrome: Three case reports.

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Posterior reversible encephalopathy syndrome (PRES) has been associated with the use of several medications, including chemotherapeutic agents.A 65-year-old woman was diagnosed with adenocarcinoma of the ovary, after sixth-line treatment with topotecan, at
To use our intra-arterial chemotherapy (IAC) rabbit model to assess the impact of IAC procedure, drug, dose, and choice of technique on ocular structure and function, to study the nature and etiology of IAC toxicity, and to compare to observations in
OBJECTIVE To investigate on the safety and efficacy of intravitreous chemotherapy for retinoblastoma seeding in a relatively large cohort and provide information on the necessary number of injections and long-term control. METHODS Retrospective interventional case series of 40 consecutive eyes with

Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE To report on our 3-year experience with the use of superselective ophthalmic artery infusion of chemotherapy as initial, primary treatment for intraocular retinoblastoma. METHODS Prospective, institutional review board-approved clinical trial. METHODS Twenty-eight eyes of 23 newly
UNASSIGNED To evaluate the effectiveness and complications of intra-arterial chemotherapy (IAC) for treating advanced refractory retinoblastoma (RB) in a large single-center cohort. UNASSIGNED Eighty-four eyes of 62 consecutive patients with advanced refractory RB who received IAC were included in
BACKGROUND The feasibility and results of intraarterial chemotherapy, also termed ophthalmic artery chemosurgery (OAC), for retinoblastoma in less developed countries have seldom been reported. METHODS A retrospective evaluation of a program of OAC in Argentina from 2010 to
OBJECTIVE To analyze our 5-year experience of intra-arterial chemotherapy (IAC) for retinoblastoma as primary or secondary therapy. METHODS Retrospective interventional case series. METHODS A total of 70 eyes of 67 patients. METHODS Ophthalmic artery chemotherapy infusion under fluoroscopic guidance
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