The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. Torreya nucifera extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extracting Torreya nucifera leaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.

Korea Research Institute of Bioscience and Biotechnology

Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera as an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera not only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

torreya nucifera/hyperlipidemias

Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

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