xanthurenic acid/seizures

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Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids.

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Logi sisse

Picolinic, kynurenic, xanthurenic and anthranilic acids are metabolites of L-kynurenine which, when administered intraperitoneally (i.p.) antagonized (in descending order of potency) the seizures induced by intracerebroventricular (i.c.v.) injections of l-kynurenine sulfate in SHR and C57BL/6 mice.

Kynurenines and audiogenic excitement in mice.

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Logi sisse

Adult male and female albino mice (SHR strain) responded to sound by locomotor excitement (73-81%), running fits (33-47%), clonic convulsions (15-25%), tonic extension (10-22%) and lethality (7-17%). Intraperitoneal injection of metabolites of tryptophan on the kynurenine pathway (Kynurenines): DL-

The effect of cycloserine on pyridoxine-dependent metabolism in tuberculosis.

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Logi sisse

Measurements were made of urinary tryptophan metabolites of 13 tuberculosis patients in order to reveal characteristics of pyridoxine-dependent metabolism before and during cycloserine treatment. The abnormally high level of xanthurenic acid excretion in untreated patients suggests a decreased

[Synergism of picrotoxin with the endogenous convulsants kynurenine and quinolinic acid and its antagonism with their antagonists].

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Logi sisse

In experiments on mice the existence of common mechanisms of action was revealed in picrotoxin and kynurenine and quinolinic acid. Picrotoxin selectively potentiated convulsions induced by kynurenine and quinolinic acid and the antagonists of these endogenous convulsants--picolinic, kynurenic and

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.

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Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles

Effects of levetiracetam on astroglial release of kynurenine-pathway metabolites.

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Logi sisse

OBJECTIVE Several preclinical studies have demonstrated the unique profiles of levetiracetam (LEV), inhibits spontaneous absence epilepsy models but does not affect traditional convulsion models; however, the detailed pharmacological mechanisms of action of LEV remain to be clarified. METHODS We

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