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BACKGROUND
Mass treatment with azithromycin is a central component of the new World Health Organization (WHO) strategy to eradicate yaws. Empirical data on the effectiveness of the strategy are required as a prerequisite for worldwide implementation of the plan.
METHODS
We performed repeated
OBJECTIVE
Opioids are indispensable for pain treatment but may cause serious nausea and vomiting. The mechanism leading to these complications is not clear. We investigated whether an opioid effect on the vestibular system resulting in corrupt head motion sensation is causative and, consequently,
When combined vestibular and visual (optokinetic) stimuli were given to squirrel monkeys in a direction and phase mismatching sinusoidal mode (in yaw plane), five of six monkeys exhibited actual emesis during three repeated exposures on separate trial days. Two animals vomited on two trial days and
The vestibular organ is a sensor that measures angular and linear accelerations with six degrees of freedom (6DF). Complete or partial defects in the vestibular organ results in mild to severe equilibrium problems, such as vertigo, dizziness, oscillopsia, gait unsteadiness nausea and/or vomiting. A