Angelica Gigas Dietary Supplements and Human Immune Cells
کلید واژه ها
خلاصه
تاریخ
آخرین تأیید شده: | 02/29/2020 |
اولین ارسال: | 08/08/2018 |
ثبت نام تخمینی ارسال شد: | 08/12/2018 |
اولین ارسال: | 08/13/2018 |
آخرین بروزرسانی ارسال شده: | 03/03/2020 |
آخرین به روزرسانی ارسال شده: | 03/04/2020 |
تاریخ شروع مطالعه واقعی: | 02/05/2019 |
تاریخ تخمین اولیه اولیه: | 07/31/2020 |
تاریخ برآورد مطالعه: | 07/31/2020 |
شرایط یا بیماری
مداخله / درمان
Dietary Supplement: Cogni.Q
Other: Placebo
فاز
گروههای بازو
بازو | مداخله / درمان |
---|---|
Experimental: Cogni.Q 800 mg per day (Two 200 mg capsules in the morning and two 200 mg capsules in the evening) for 21 days | |
Placebo Comparator: Placebo Two capsules in the morning and two capsules in the evening for 21 days |
معیارهای صلاحیت
سنین واجد شرایط تحصیل | 21 Years به 21 Years |
جنسیت واجد شرایط مطالعه | Male |
داوطلبان سالم را می پذیرد | آره |
شاخص | Inclusion Criteria: - Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in the range of 19 to 30 - Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR, see supporting document for normal reference ranges). - Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg) Exclusion Criteria: - Subjects positive for HIV, HBV and HCV (self-reported) - Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded. Therefore, subjects with diabetes, major cardiovascular diseases, cancer, severe hypertension, severe hepatic cirrhosis or cirrhosis of the liver, and kidney disease (self-reported) will be excluded. - Subjects using tobacco products, nicotine patches and excessive alcohol - Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study. - Non-English-speaking subjects |
نتیجه
اقدامات اولیه
1. Neutrophil counts and NK cell counts in peripheral blood [70 days]
اقدامات ثانویه
1. T cells in peripheral blood, [70 days]
2. Plasma concentrations of pyranocoumarins, androgens, and inflammatory/anti-inflammatory cytokines. [70 days]
3. Lipid profiling [70 days]
4. NK mRNA signature [70 days]
5. PBMC isolation for testing NK activity [70 days]
6. CMP-EGFR [70 days]