Assessment of Neopterin Levels in Pre- and Post-menopausal Women With Chronic Periodontitis
کلید واژه ها
خلاصه
شرح
A total of 30 patients will be selected, 15 per-menopause and 15 post-menopausal women. Full mouth scaling and root planing will be performed. All clinical parameters will be recorded at the baseline visit before mechanical debridement and after 3 months of treatment. Saliva samples will be collected at the primary visit before scaling and root planing as a baseline value, and after 1 month and 3 months postoperatively. Gingival crevicular fluid (GCF) samples will be collected at the primary visit before scaling and root planing as a baseline value, and after 1 month and 3 months postoperatively. Neopterin will be measured in the samples using commercially available Enzyme Linked Immunosorbent Assay (ELISA) kit. Statistical analysis will be performed to the results.
تاریخ
آخرین تأیید شده: | 09/30/2019 |
اولین ارسال: | 10/18/2019 |
ثبت نام تخمینی ارسال شد: | 10/23/2019 |
اولین ارسال: | 10/27/2019 |
آخرین بروزرسانی ارسال شده: | 10/23/2019 |
آخرین به روزرسانی ارسال شده: | 10/27/2019 |
تاریخ شروع مطالعه واقعی: | 01/24/2019 |
تاریخ تخمین اولیه اولیه: | 04/24/2019 |
تاریخ برآورد مطالعه: | 04/29/2019 |
شرایط یا بیماری
مداخله / درمان
Diagnostic Test: assessment of neopterin levels
فاز
گروههای بازو
بازو | مداخله / درمان |
---|---|
Other: saliva neopterin levels assessment of saliva neopterin levels in pre and post-menopausal women | |
Other: GCF neopterin levels assessment of GCF neopterin levels in pre and post-menopausal women |
معیارهای صلاحیت
سنین واجد شرایط تحصیل | 35 Years به 35 Years |
جنسیت واجد شرایط مطالعه | Female |
داوطلبان سالم را می پذیرد | آره |
شاخص | Inclusion Criteria: - Female patients aged from (35- 60). - Clinically diagnosed with chronic moderate periodontitis having more than 10 natural teeth and at least two teeth exhibiting clinical attachment loss (CAL) ≥4 mm. - Systemically healthy individuals and not taking any hormonal therapy or drugs that affect hormonal status. - Patient compliance Exclusion Criteria: - Smokers. - Pregnant or lactating females. - Periodontal treatment <6 months prior to the preliminary visit. |
نتیجه
اقدامات اولیه
1. assess salivary and gingival crevicular fluid neopterin levels in patients with chronic periodontitis in pre- and post-menopausal women [3 months]
اقدامات ثانویه
1. evaluate the value of neopterin as a biomarker [3 months]