Berberis Vulgaris Consumption and Blood Pressure

فقط کاربران ثبت نام شده می توانند مقالات را ترجمه کنند

ورود به سیستم / ثبت نام

پیوند در کلیپ بورد ذخیره می شود

وضعیتاستخدام

حامیان مالی

Shahid Beheshti University

کارازمایی بالینی: NCT04084847

BioSeek: nct04084847

کلید واژه ها

خلاصه

The aim of this study is to investigate the effect of barberry consumption on systolic and diastolic blood pressure, serum lipids, and inflammatory status. The study will involve cases having elevated BP (129/ < 85) and known hypertensive patients on medical treatment. Seventy people will be randomized into two groups, including intervention (barberry) or placebo groups.

Before and after of 8 week intervention, 24-hour ambulatory blood pressure monitoring will be done and fasting venous blood sample will be taken to measure plasma lipids. In addition, 24-hour urine will be collected to measure its sodium content and estimate sodium intake.

تاریخ

آخرین تأیید شده:	03/31/2020
اولین ارسال:	09/02/2019
ثبت نام تخمینی ارسال شد:	09/06/2019
اولین ارسال:	09/09/2019
آخرین بروزرسانی ارسال شده:	04/10/2020
آخرین به روزرسانی ارسال شده:	04/13/2020
تاریخ شروع مطالعه واقعی:	09/17/2019
تاریخ تخمین اولیه اولیه:	03/18/2020
تاریخ برآورد مطالعه:	05/31/2020

شرایط یا بیماری

Blood Pressure

Cardiovascular Risk Factor

Lipid Profile

مداخله / درمان

Dietary Supplement: Barberry

Dietary Supplement: placebo

فاز

گروههای بازو

بازو	مداخله / درمان
Active Comparator: Barberry Daily consumption of barberry in powder form.	Dietary Supplement: Barberry 10 grams of barberry powder will be consumed daily for 8 weeks.
Placebo Comparator: placebo Daily consumption of placebo powder.	Dietary Supplement: placebo Placebo powder

معیارهای صلاحیت

سنین واجد شرایط تحصیل	20 Years به 20 Years
جنسیت واجد شرایط مطالعه	All
داوطلبان سالم را می پذیرد	آره
شاخص	Inclusion Criteria: - willingness to participate in the study - age between 20-65 years - having elevated BP (129/ < 85) and known hypertensive patients on medical treatment - at least one other classical cardiovascular disease risk factors, including hyperlipidemia or diabetes mellitus Exclusion Criteria: - Unwillingness to continue participation - BMI> 30 - patients on nitrates - high doses of statins consumption (Atorvastatin>40 mg/day or Rosuvastatin>20 mg/day) - consumption of vitamins or minerals supplements during past month - Chronic kidney disease stage 4 or 5

نتیجه

اقدامات اولیه

1. blood pressure [at 8 weeks]

mean of systolic and diastolic blood pressure of participants measured by ambulatory 24 hour blood pressure monitoring

اقدامات ثانویه

1. lipid profile [at 8 weeks]

plasma TC, LDL-C, HDL-C, TG

2. plasma NOx [at 8 weeks]

concentration of nitrite and nitrate in plasma

3. Inflammatory cytokine [at 8 weeks]

Plasma Interleukin-6

Berberis Vulgaris Consumption and Blood Pressure

کلید واژه ها

التهاب

زرشک تبتی

زرشک خوراکی

زرشک