Hyperbaric Oxygen Treatment in Autism Spectrum Disorders
کلید واژه ها
خلاصه
شرح
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in verbal and non-verbal communication and social interactions. People with ASD often exhibit difficult behaviors, including aggressiveness, temper tantrums, irritability, hyperactivity, inattention, impulsivity, self-harm ..
The increasing prevalence of autism spectrum disorders (approximately 1%) has increased the need for evidence-based treatment to lessen the impact of symptoms.
The ethiopathogenesis of ASD has so far been unclear. Current pathophysiological theories have demonstrated the presence of cerebral hypo-perfusion, neuro-inflammation, immune dysregulation and oxidative stress involved in the genesis of this disorder. Based on its anti-inflammatory effects and increased amount of dissolved oxygen, hyperbaric oxygen therapy has been tried as one of the therapeutic arsenals of adjuvant therapy for autism.
This is a randomized controlled study including nearly 80 patients with ASD who underwent clinical and neuropsychological evaluation before and after HBOT treatment as well as the dosage of the various biochemical and immunological markers. These markers will be assessed before and after the HBOT. Perfusion MRI would also be performed before and after HBO.
تاریخ
| آخرین تأیید شده: | 06/30/2020 |
| اولین ارسال: | 06/02/2020 |
| ثبت نام تخمینی ارسال شد: | 07/13/2020 |
| اولین ارسال: | 07/14/2020 |
| آخرین بروزرسانی ارسال شده: | 07/13/2020 |
| آخرین به روزرسانی ارسال شده: | 07/14/2020 |
| تاریخ شروع مطالعه واقعی: | 05/31/2019 |
| تاریخ تخمین اولیه اولیه: | 12/31/2020 |
| تاریخ برآورد مطالعه: | 01/31/2021 |
شرایط یا بیماری
مداخله / درمان
Device: HBOT Group
فاز
گروههای بازو
| بازو | مداخله / درمان |
|---|---|
| Experimental: HBOT Group will benefit from HBOT | Device: HBOT Group HBOT therapy protocol: in an eight-seat hyperbaric chamber 40 sessions of HBOT duration: 1 hour rhythm: 5 sessions / week pressure: 1.7 ATA (7 meters) O2 concentration: 100% |
| No Intervention: Control group will benefit from the conventional treatment |
معیارهای صلاحیت
| سنین واجد شرایط تحصیل | 4 Years به 4 Years |
| جنسیت واجد شرایط مطالعه | All |
| داوطلبان سالم را می پذیرد | آره |
| شاخص | Inclusion Criteria: - All children aged 4 to 14 years who were followed in the child psychiatry unit during the study period and who were identified as having a diagnosis of ASD. This diagnosis was made by child psychiatrists experienced in autism using the DSM-5 criteria and the ADI and the Childhood Autism Rating Scale (CARS) Criteria for non-inclusion : - Children with hearing or visual impairments - Children with unbalanced epilepsy - Children with a contraindication to HBOT - Dysfunction of the immune system Exclusion criteria -Child that havent completed entire protocol |
نتیجه
اقدامات اولیه
1. clinical severity assesement [03 months]
اقدامات ثانویه
1. dosage of Inetreleukine 6 [03 months]
2. dosage of TNFα [03 months]
3. Oxidatif stress profil [03 months]
4. dosage of Glutathione peroxidase [03 months]
