Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris
کلید واژه ها
خلاصه
شرح
Chemical peeling is one of the most common cosmetic procedures in medical practice and has been used for decades. It is defined as the application of chemical agents, of variable strength, on the skin that results in controlled destruction of the epidermis and dermis. The induced exfoliation is followed by dermal and epidermal regeneration from adjacent epithelium and skin adnexa, which results in improved surface texture and appearance of the skin. This is a simple and cost-effective procedure with several dermatological applications.
Salicylic acid is a 2-hydroxybenzoic acid used for superficial peeling due to its strong keratolytic and comedolytic properties. It promotes shedding of epidermal cells and due to its lipophilic properties can penetrate comedones and pores to prevent clogging and neutralize bacteria. It promotes desquamation of the upper lipophilic layers of the stratum corneum. These chemical properties explain its popularity and success in acne patients. Also, it has well-documented anti-inflammatory properties.
Silymarin is a standardized extract from S. marianum seeds, is traditionally used as a hepatoprotective agent for its potent regenerative properties. Lately, Silymarin is utilized in dermatological and cosmetic preparations for its antioxidant effect anti-inflammatory and immunomodulatory properties.
Various studies have been created to evaluate the efficacy of Silymarin in UV protection, prevention against skin cancer and against actinic keratosis.
Silymarin showed efficacy the treatment of Rosacea, Melasma, Vitiligo, Psoriasis, atopic dermatitis and contact dermatitis . Other studies showed that Silymarin has anti aging properties and potential action for wound healing .
تاریخ
آخرین تأیید شده: | 06/30/2020 |
اولین ارسال: | 07/19/2020 |
ثبت نام تخمینی ارسال شد: | 07/26/2020 |
اولین ارسال: | 07/28/2020 |
آخرین بروزرسانی ارسال شده: | 07/26/2020 |
آخرین به روزرسانی ارسال شده: | 07/28/2020 |
تاریخ شروع مطالعه واقعی: | 08/31/2020 |
تاریخ تخمین اولیه اولیه: | 08/31/2021 |
تاریخ برآورد مطالعه: | 11/30/2021 |
شرایط یا بیماری
مداخله / درمان
Combination Product: Silymarin and salicylic acid
Procedure: Silymarin and salicylic acid
فاز
گروههای بازو
بازو | مداخله / درمان |
---|---|
Experimental: Silymarin and salicylic acid There will be one group of patients, that will use salicylic acid peeling on the right side of the face and topical Silymarin cream on the left side | Combination Product: Silymarin and salicylic acid Silymarin 1.4% cream will be used on the left side of the face twice daily (home use). |
معیارهای صلاحیت
سنین واجد شرایط تحصیل | 18 Years به 18 Years |
جنسیت واجد شرایط مطالعه | All |
داوطلبان سالم را می پذیرد | آره |
شاخص | Inclusion Criteria: - Patients older than 18 years of age. - Patients with mild and moderate acne vulgaris. - Patients with Fitzpatrick skin type III, IV and V. Exclusion Criteria: - Severe acne. - Patients under treatment with contraceptive pills or any kind of systemic or topic acne medication (isotretinoin, antibiotics, topical products). - History of hypertrophic/keloid scar formation. - Pregnancy. - Recurrent herpes infection. |
نتیجه
اقدامات اولیه
1. Efficacy of the medication: number of inflammatory, non-inflammatory and total lesions [12 weeks]
2. assessment of tolerability: interviewing the patients [12 weeks]