The United Kingdom Multiple Sclerosis Register Covid-19 Substudy
کلید واژه ها
خلاصه
شرح
Study objectives
1. To identify the incidence of upper respiratory tract symptoms: fever, cough and breathing difficulties, other symptoms suggestive of COVID-19 infection, respiratory tract infections suggestive of COVID-19, and COVID-19 confirmed by laboratory testing among the UK MS population
2. To establish if some DMDs increase the risk of COVID-19 infection
3. To determine the incidence and effectiveness of self-isolation in the MS population. To examine the impact self-isolation has on mood, fatigue, and other routinely collected patient reported outcome measures from the MS Register.
4. To determine the clinical outcome of respiratory tract infections, including confirmed and suspected cases of COVID-19, in terms of symptoms, time to recovery, hospital admission, requirement for ventilation, and death.
5. To determine the longer-term impact of COVID-19 on MS, using routinely collected MS outcomes in the MS register, including impact on disability, relapses and changes in DMDs as assessed at 3 monthly intervals.
6. To determine where people are obtaining their health information during the COVID-19 outbreak.
7. To establish changes in DMDs prior to and as a result of symptoms related and unrelated to COVID-19
تاریخ
| آخرین تأیید شده: | 02/29/2020 |
| اولین ارسال: | 04/05/2020 |
| ثبت نام تخمینی ارسال شد: | 04/19/2020 |
| اولین ارسال: | 04/20/2020 |
| آخرین بروزرسانی ارسال شده: | 06/18/2020 |
| آخرین به روزرسانی ارسال شده: | 06/21/2020 |
| تاریخ شروع مطالعه واقعی: | 03/13/2020 |
| تاریخ تخمین اولیه اولیه: | 07/13/2021 |
| تاریخ برآورد مطالعه: | 07/13/2022 |
شرایط یا بیماری
فاز
گروههای بازو
| بازو | مداخله / درمان |
|---|---|
| Confirmed Cases Diagnosed by health professional / Covid-19 test
Monitored through fortnightly questionnaires | |
| Not Covid-19 cases Through self report no suspicion of COVID-19, tested by fortnightly questionnaire.
non Covid Cases can become COVID cases through self report. | |
| Suspected Covid-19 Cases Participants that are suspected of having Covid-19 but this has not been confirmed by health professional or Covid-19 test has not been performed.
Fortnighly questionnaire |
معیارهای صلاحیت
| سنین واجد شرایط تحصیل | 18 Years به 18 Years |
| جنسیت واجد شرایط مطالعه | All |
| روش نمونه گیری | Non-Probability Sample |
| داوطلبان سالم را می پذیرد | آره |
| شاخص | Inclusion Criteria: - >18 and confirmed diagnosis of MS, enrolled on UK MS Register Exclusion Criteria: - None of the above |
نتیجه
اقدامات اولیه
1. Incidence of COVID-19 Infections within an MS Cohort in the UK [Through study completion, an average of 1 year]
2. Hospitalisations in MS Patients with COVID-19 [1 Year (regular outputs)]
3. Mortality [1 Year from study commencement]
اقدامات ثانویه
1. Patient Reported Expanded Disability Status Score [1 year (at least 6 monthly)]
2. Hospital Anxiety and Depression Scale [1 year (at least 6 monthly)]
3. Multiple Sclerosis Impact Scale 29 V2 [1 year (at least 6 monthly)]
4. Multiple Sclerosis Walking Scale 12 V2 [1 year (at least 6 monthly)]
5. Fatigue Severity Scale [1 year (at least 6 monthly)]
6. EuroQol 5D (3l) [1 year (at least 6 monthly)]
