Haemostasis Disorders

Systemic sampling is performed six times:
before the surgery (S1)
during the hepatectomy, 10 minutes before the anhepatic phase (S2)
in the anhepatic phase, before starting portal vein anastomosis: (S3)
in the neohepatic phase, 15 minutes after releasing portal vein clamping: (S4)
in the neohepatic phase, at the end of the surgery: (S5)
Regional sampling from the portal vein representing afferent flow to the liver is performed once:
• in the anhepatic phase, before starting portal vein anastomosis: (R)
Simultaneously with haemostasis and blood gas analyses, the following investigations will be performed (the following tests are also routinely performed at the given time points, independently of this study):
haemodynamic measurements by PiCCO
arterial blood gas analysis from radial artery catheter
central venous blood gas analysis from subclavian vein catheter
blood temperature measurement in the femoral artery by PiCCO catheter
hourly urinary output

TEG® and ClotPro® parameters

Semmelweis University

Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG®

Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG ® Viscoelastic Tests

If there is correlation between TEG® and ClotPro® parameters:
reaction time (R) in citrated kaolin TEG (CK-TEG) and clotting time (CT) in IN-test (ClotPro®)
kinetics (K) in CK-TEG and clot formation time (CFT) in IN-test
Alpha-angel in CK-TEG and IN-test
maximum amplitudo (MA) in CK-TEG and maximum clot firmness (MCF) in IN-test
percent rate of lysis (Ly30) in CK-TEG and clot lyzis index (CLI30) in IN-test

If there is a significant difference between the systemic and the portal haemostasis before graft reperfusion:
R, K, Alpha-angel, MA, MCF and Ly30 in CK-TEG from systemic and portal sample
CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test from systemic and portal sample
Conventional laboratory tests: international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), factor V (FV), factor VII (FVII), factor X (FX), factor XIII (FXIII) from systemic and portal sample
Blood gas analysis: pH, pCO2, pO2, sodium, potassium, ionised calcium, blood glucose, lactate, bicarbonate, base excess, haemoglobin, haematocrit from systemic and portal sample

Child-Turcotte-Pugh (CTP) score and CK-TEG (R, K, Alpha-angel, MA, MCF and Ly30) parameters from systemic and systemic samples
CTP score and ClotPro (CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test) parameters from systemic and portal samples
Model for End-stage Liver Disease (MELD) score and CK-TEG (R, K, Alpha-angel, MA, MCF and Ly30) parameters from global and systemic samples
MELD score and ClotPro (CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test) parameters from systemic and portal samples
MELD-Na score and CK-TEG (R, K, Alpha-angel, MA, MCF and Ly30) parameters from systemic and portal samples
MELD-Na score and ClotPro (CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test) parameters from systemic and portal samples

If there is a correlation between local and systemic haemostasis and any subsequent coagulopathic or thrombotic complications (reoperation for haemorrhage, portal vein or hepatic artery thrombosis).
Need for reoperation due to haemorrhage and CK-TEG (R, K, Alpha-angel, MA, MCF and Ly30) parameters from systemic and portal samples
Need for reoperation due to haemorrhage and ClotPro (CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test) parameters from systemic and portal samples
Need for reoperation due to portal vein or hepatic artery thrombosis and CK-TEG (R, K, Alpha-angel, MA, MCF and Ly30) parameters from systemic and portal samples
Need for reoperation due to portal vein or hepatic artery thrombosis and ClotPro (CT, CFT, Alpha-angel, MCF, CLI30 in EX-test, IN-test, FIB-test, TPA-test, RVV-est, ECA-test) parameters from systemic and portal samples

glutamate pyruvate transaminase/سکته مغزی

Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG®

کاملترین پایگاه داده گیاهان دارویی با پشتیبانی علمی