Patients with Rheumatoid Arthritis (RA) fulfilling the American College of Rheumatology and European League Against Rheumatism 2009 criteria.

Patients with Psoriatic Arthritis (PsA) fulfilling the Classification for PsA (CASPAR) criteria.

Anonymous healthy donors from the Etablissement Français du Sang.

Rheumatoid Arthritis

Psoriatic Arthritis

Collection of venous blood (16 mL) and synovial fluid (when available) samples, for each patient, at inclusion and in the frame of the usual medical follow-up at 3 months and between 6 and 12 months, before the onset of MTX (untreated patients) or during the course of MTX treatment (MTX-treated patients).
Collection of anonymous healthy donors blood samples, age- and sex-matched, obtained from the Etablissement Français du Sang.
Multi-parametric Flow Cytometry analysis was performed on these samples to assess CD73 expression on total memory T cells and within T helper lymphocyte subsets, their cytokine production and AMPase functions. For FoxP3 intracellular staining, cells were treated using the FoxP3 Fixation and Permeabilization kit (Life Technologies), according to manufacturer instructions. Stainings were analyzed on a LSR-Fortessa™ (BD Biosciences) with conserved settings throughout the entire study and data were analyzed using FlowJo™ Software (Tree Star v10.4).

Multi-parametric Flow Cytometry analysis on patients and healthy donors samples

Service de Rhumatologie, Centre Hospitalier Lyon-Sud (HCL)

CD73+ Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis

Presence and Impact of CD73+ Th1.17 and of the CD39/CD73/Adenosine Cascade in Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA)

Determine CD73 expression on T helper lymphocyte subpopulations (using multi-parametric Flow Cytometry), in the blood and synovial fluid of Rheumatoid Arthritis (RA) or Psoriatic Arthritis (PsA) patients before or under MTX treatment.

Hospices Civils de Lyon

Platelet Aggregation Inhibitors

Anti-inflammatory Agent

Myocardial Reperfusion Injury

Loading: aspirin 300mg + clopidogrel 600mg
Maintenance: aspirin 200mg/d + clopidogrel 75mg/d for 1 month

Dual Anti-Platelet Therapy (DAPT)

Loading: cilostazol 200mg + aspirin 300mg + clopidogrel 600mg
Maintenance: cilostazol 100mg bid+ aspirin 200mg/d+ clopidogrel 75mg/d for 1 month

Triple Anti-Platelet Therapy (TAPT)

Gyeonsang National University Hospital

ACCEL-LOADING-ACS Study

ACCELerated Inhibition of Platelet Aggregation, Inflammation and Ischemia-reperfusion Injury by Adjunctive Cilostazol Loading in Patients With Acute Coronary Syndrome

Composite of cardiac death, MI and ischemia-driven target lesion revascularization (TLR)

Gyeongsang National University Hospital

Endotoxemia

Endotoxin 2ng/kg to subjects with a AMPD1 polymorphism

AMPD1 polymorphism

Endotoxin 2ng/kg combined with caffeine. Caffeine (4mg/kg) is used as an adenosine receptor antagonist.

nucleotidase/التهاب

CD73+ Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis

ACCEL-LOADING-ACS Study

A Possible Therapeutic Role for Adenosine During Inflammation

کاملترین پایگاه داده گیاهان دارویی با پشتیبانی علمی