Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5'-nucleotidase, ecto is also provided.

ARCUS BIOSCIENCES, INC.

Modulators of 5'-nucleotidase, ecto and the use thereof

The subject matter of the present invention is compounds which have a 6-aminopurine backbone corresponding to formula (I): in which R.sub.1, R.sub.2, R.sub.3, X, Y and Z are as defined in any one of claims 1 to 5, and Ar is a biphenyl or a naphthyl which may be substituted with R.sub.3, for use in the treatment of cancer. ##STR00001##

Centre National de la Recherche Scientifique-CNRS

Hospices Civils de Lyon

Ecole Normale Superieure de Lyon

Universite Claude Bernard Lyon 1

Universite de Montpellier 1

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS

HOSPICES CIVILS DE LYON

ECOLE NORMALE SUPERIEURE DE LYON

UNIVERSITE CLAUDE BERNARD LYON 1

UNIVERSITE DE MONTPELLIER 1

5'-nucleotidase inhibitors and therapeutic uses thereof

nucleotidase

سرطان

neoplasms

nucleotidase/سرطان

Modulators of 5'-nucleotidase, ecto and the use thereof

5'-nucleotidase inhibitors and therapeutic uses thereof

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