صفحه 1 از جانب 25 نتایج
TECHNICAL FIELD OF THE DISCLOSURE
The present disclosure is generally related to probes and methods advantageous for detecting pyruvate kinase M2 in cells. The present disclosure is further generally related to methods of imaging tumors by detecting pyruvate kinase M2 activity using positron
TECHNICAL FIELD OF THE DISCLOSURE
The present disclosure is generally related to probes and methods advantageous for detecting pyruvate kinase M2 in cells. The present disclosure is further generally related to methods of imaging tumors by detecting pyruvate kinase M2 activity using positron
BACKGROUND OF THE INVENTION
(a) Field of the Invention
The invention relates to novel inhibitors of pyruvate kinase and ATP production specific for the treatment of cancer, pharmaceutical compositions and methods of treatment of cancer thereof.
(b) Description of Prior Art
Most malignant tumors have
BACKGROUND OF THE INVENTION
Pyruvate kinase (PK) is a critical metabolic enzyme operating at the ultimate step in glycolysis where it catalyzes the transfer of a phosphate group from phosphoenolpyruvate to adenosine diphophate (ADP), yielding one molecule of pyruvate and one molecule of adenosine
BACKGROUND OF THE INVENTION
Pyruvate kinase (PK) is a critical metabolic enzyme operating at the ultimate step in glycolysis where it catalyzes the transfer of a phosphate group from phosphoenolpyruvate to adenosine diphophate (ADP), yielding one molecule of pyruvate and one molecule of adenosine
BACKGROUND OF THE INVENTION
Pyruvate kinase (PK) is a critical metabolic enzyme operating at the ultimate step in glycolysis where it catalyzes the transfer of a phosphate group from phosphoenolpyruvate to adenosine diphophate (ADP), yielding one molecule of pyruvate and one molecule of adenosine
BACKGROUND OF THE INVENTION
Pyruvate kinase (PK) is a critical metabolic enzyme operating at the ultimate step in glycolysis where it catalyzes the transfer of a phosphate group from phosphoenolpyruvate to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of adenosine
BACKGROUND OF THE INVENTION
The invention described herein features methods, compositions, and kits for the use of inhibitors of pyruvate kinase M2 (PKM2) to treat diseases related to pyruvate kinase function, including, e.g., cancer, diabetes, obesity, autoimmune disorders, and benign prostatic
The present invention relates to a method for the detection of a malignant process in the gastrointestinal tract of humans or animals.
In particular, the present invention concerns a method for the selective, qualitative or/and quantitative detection of the pyruvate kinase isoenzyme of the type
BACKGROUND OF THE INVENTION
Pyruvate kinase (PK) is a critical metabolic enzyme operating at the ultimate step in glycolysis where it catalyzes the transfer of a phosphate group from phosphoenolpyruvate to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of adenosine
BACKGROUND OF INVENTION
Cancer cells rely primarily on glycolysis to generate cellular energy and biochemical intermediates for biosynthesis of lipids and nucleotides, while the majority of "normal" cells in adult tissues utilize aerobic respiration. This fundamental difference in cellular
BACKGROUND OF INVENTION
Cancer cells rely primarily on glycolysis to generate cellular energy and biochemical intermediates for biosynthesis of lipids and nucleotides, while the majority of "normal" cells in adult tissues utilize aerobic respiration. This fundamental difference in cellular
BACKGROUND OF INVENTION
Cancer cells rely primarily on glycolysis to generate cellular energy and biochemical intermediates for biosynthesis of lipids and nucleotides, while the majority of "normal" cells in adult tissues utilize aerobic respiration. This fundamental difference in cellular
BACKGROUND OF INVENTION
Cancer cells rely primarily on glycolysis to generate cellular energy and biochemical intermediates for biosynthesis of lipids and nucleotides, while the majority of "normal" cells in adult tissues utilize aerobic respiration. This fundamental difference in cellular
BACKGROUND OF INVENTION
Cancer has become the most common death cause disease in China. Carcinoma of the lungs is a leading one among all cancers. Although lots of medicines and therapy methods thereof were invented, the largest obstruction was still the drug resistance.
Cancer cells, different from