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[Determination of sarsasapogenin in Anemarrhena asphodeloides Bunge by GC].

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OBJECTIVE To determine sarsasapogenin in Anemarrhena asphodeloides. METHODS Chloromethane extract (1 microliter) with cholesterol as internal standard was analyzed on HP-1 column, operated at 270 degrees C with N2 as carrier gas and FID. RESULTS The method was linear within the range of 0.245-2.94

[TLC-densitometric determination of sarsasapogenin in Anemarrhena asphodeloides Bge].

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The sarsasapogenin content in Anemarrhena asphodeloides and its preparations was assayed by TLC-densitometric method. The developing solvent used was benzene-acetone (9:1). The chromatographic plate was sprayed with a mixture of 8% vanillin in alcoholic solution-70% H2SO4 solution (0.5:5). This

Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae).

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The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae) on two experimental models of depression in rats. After a two-week treatment, sarsasapogenin markedly shortened the immobility time in the forced swimming test and decreased the

Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae).

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The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic activities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50

The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells.

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Sarsasapogenin, a kind of mainly effective components of Anemarrhena asphodeloides Bunge (Liliaceae) has the effects of being anti-diabetes and improving memory. However, there are few reports focusing on its anti-tumor effects. In this study, the sarsasapogenin was extracted from rhizomes of A.

[Studies on accumulation of active ingredients, N, P and K in Anemarrhena asphodeloides].

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OBJECTIVE To study the accumulation of active ingredients, the absorption and transformation of N, P and K in Anemarrhena asphodeloides and provide basis for determination of the harvest time and fertilizing. METHODS Samples were collected in different phrases and the weight of dry matter, the

Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus.

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To investigate the antiallergic effect of the rhizome of Anemarrhena asphodeloides (AA, family Liliaceae), which was found to inhibit the mouse passive cutaneous anaphylaxis (PCA) reaction induced by the antigen-immunoglobulin E (IgE) complex in preliminary experiments, main steroidal saponins,

[Investigation on the technology of processing Anemarrhena asphodeloides Bge. without hair by water].

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OBJECTIVE To research the best processing method of Anemarrhena asphodeloides Bge. without hair by water. METHODS L9(3)4 orthogonal table were decided with three effect factors: moistening time, temperature, thickness. According to the amount of sarsasapogenin and mangiferin, Orthogonal design was

[Quality Analysis and Evaluation of Anemarrhena asphodeloides Rhizome from Different Habitats].

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tive: To compare and analyze the quality of Anemarrhena asphodeloides rhizome from different habitats. METHODS Simultaneous determination of nine components in Anemarrhena asphodeloides rhizome by UPLC-TQ/MS was performed on a Phenomenex Kinetex XB-C18 (100 mm x 2.1 mm, 1.7 μm) column with the

Synthesis and SAR study of novel sarsasapogenin derivatives as potent neuroprotective agents and NO production inhibitors.

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Sarsasapogenin, isolated from rhizomes of Anemarrhena asphodeloides, was found to be able to enhance memory. On the basis of the structure of Sarsasapogenin, a series of derivatives were synthesized and evaluated for their neuroprotective activity in PC12 cells and NO production inhibitory activity

Synthesis and evaluation of 26-amino acid methyl ester substituted sarsasapogenin derivatives as neuroprotective agents for Alzheimer's disease.

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Sarsasapogenin, extracted from Anemarrhena asphodeloides Bunge., has been reported to protect neurons from H2O2-induced damage. In the current study, four series of 26-amino acid methyl ester substituted sarsasapogenin derivatives (5a-5e, 5f-5j, 6a-6e and 7a-7e) were synthesized and tested for

Quantitative determination of sarsasapogenin in rat plasma using liquid chromatography-tandem mass spectrometry.

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Sarsasapogenin, a natural compound from Chinese medical herb Anemarrhena asphodeloides Bge., has recently received a great deal of attention due to its various bioactivities. In this study, an easy and applicable liquid chromatography tandem mass spectrometry method for the quantification of

A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia.

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OBJECTIVE To identify whether sarsasapogenin, a sapogenin from the Chinese medicinal herb Anemarrhena Asphodeloides Bunge, would augment the efficacy of risperidone and significantly improve cognitive functions in patients with negative symptoms dominated schizophrenia. METHODS The trial was a

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice.

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Anemarrhena asphodeloides Bunge (AA, family Liliaceae), which primarily contains xantones, such as mangiferin, and steroidal saponins, such as timosaponin AIII and sarsasapogenin, has been used as an anti-pyretic, anti-inflammatory, anti-diabetic, anti-platelet aggregation, and anti-depressant agent

Synthesis of new sarsasapogenin derivatives with antiproliferative and apoptotic effects in MCF-7 cells.

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Sarsasapogenin, a kind of mainly effective component of Anemarrhena asphodeloides Bunge, possesses good antitumor properties. Two series of new sarsasapogenin derivatives were synthesized and evaluated for their cytotoxicities against three human cancer cell lines (HepG2, A549, MCF-7) using the MTT

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Herbal & Natural Medicine

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