Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin
Avainsanat
Abstrakti
Kuvaus
Efficacy was measured through improvement (decrease in fever, settling lymphadenopathy and disappearance of tonsillar exudate) in Centor Criteria score on daily basis. Improvement i.e reduction in Centor Criteria score was recorded for all children till full recovery.
Safety was measured by frequency of hypersensitivity reactions or severe side effects of antibiotics necessitating stoppage of the drug. All the children in both Groups were given test dose of the antibiotic before giving full dose of antibiotic prescribed.
Cost effectiveness was compared in terms of total cost of injections (Co-amoxiclav versus Benzyl penicillin) which were administered to children in both groups.
Päivämäärät
| Viimeksi vahvistettu: | 11/30/2019 |
| Ensimmäinen lähetys: | 12/28/2019 |
| Arvioitu ilmoittautuminen lähetetty: | 12/28/2019 |
| Ensimmäinen lähetetty: | 01/01/2020 |
| Viimeisin päivitys lähetetty: | 01/01/2020 |
| Viimeisin päivitys lähetetty: | 01/02/2020 |
| Todellinen opintojen alkamispäivä: | 12/31/2017 |
| Arvioitu ensisijainen valmistumispäivä: | 10/31/2019 |
| Arvioitu tutkimuksen valmistumispäivä: | 10/31/2019 |
Ehto tai tauti
Interventio / hoito
Drug: inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Vaihe
Varren ryhmät
| Varsi | Interventio / hoito |
|---|---|
| Active Comparator: Inj Co-amoxiclav Group A children were advised Inj Co-amoxiclav 50 units/kg/day in 3 divided doses daily | |
| Active Comparator: Inj Benzyl Penicillin Group B patients were advised inj Benzyl Penicillin 25000 units/kg/day in 3 divided doses |
Kelpoisuusehdot
| Tutkimukseen soveltuvat iät | 5 Years Vastaanottaja 5 Years |
| Sukupuolet, jotka ovat kelpoisia tutkimukseen | All |
| Hyväksyy terveelliset vapaaehtoiset | Joo |
| Kriteeri | Inclusion Criteria: 1. Children who had 3 or 4 score according to Centor Criteria for tonsillitis/pharyngotonsillitis, were included in study 2. Children between ages of 5 to 15 years 3. Children with positive Rapid Antigen detection Test (RADT) for Streptococcus Pyogenes Exclusion Criteria: 1. Immunocompromised children 2. Children with known hypersensitivity to Penicillins (esp Coamoxiclav and Benzyl penicillin) 3. Children with liver or renal failure 4. Children who were already using any oral or parenteral antibiotics |
Tulokset
Ensisijaiset tulosmittaukset
1. treatment efficacy [10 days]
