Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis
Avainsanat
Abstrakti
Kuvaus
Acute tonsillitis is based on typical symptoms (sore throat, pain on swallowing, and fever) and clinical findings of tonsillar exudate and hyperemia.
10-20% of patients seen by their family physician, have acute tonsillitis due to streptococci group A. In Denmark, Centors criteria and the Streptococcal antigen test (Strep. A-test) are gold standard in the diagnostic process of streptococcal acute tonsillitis. Although the sensitivity and specificity of the Strep. A-test is biochemically high, its clinical reliability is reduced due to several influential factors. Moreover, studies suggest that 4-10% of patients are tested false-negative based on clinical criteria and the Strep A-test.
Fusobacterium necrophorum are suspected to be the cause of acute tonsillitis in teenagers and young adults (5-15%). However, there is no rapid test available for this bacterium. Since tonsillar surface swab is not included in the diagnostic standard, family physicians get no information about infection due to Fusobacterium necrophorum or other pathogens.
C-reactive protein, leukocyte count and absolute neutrophil count as diagnostic markers are examined with variable results. Procalcitonin is a relatively new marker of bacterial infection, which has the advantage of more rapid and specific induction compared to the other markers.
Päivämäärät
| Viimeksi vahvistettu: | 12/31/2012 |
| Ensimmäinen lähetys: | 07/30/2012 |
| Arvioitu ilmoittautuminen lähetetty: | 07/31/2012 |
| Ensimmäinen lähetetty: | 08/05/2012 |
| Viimeisin päivitys lähetetty: | 01/16/2013 |
| Viimeisin päivitys lähetetty: | 01/17/2013 |
| Todellinen opintojen alkamispäivä: | 07/31/2012 |
| Arvioitu ensisijainen valmistumispäivä: | 02/28/2013 |
| Arvioitu tutkimuksen valmistumispäivä: | 02/28/2013 |
Ehto tai tauti
Vaihe
Varren ryhmät
| Varsi | Interventio / hoito |
|---|---|
| Acute tonsillitis Patients with acute tonsillitis aged 15 to 40 years meeting at least two of Centors criteria. | |
| Healthy control patients Control patients aged 15 to 40 years. |
Kelpoisuusehdot
| Tutkimukseen soveltuvat iät | 15 Years Vastaanottaja 15 Years |
| Sukupuolet, jotka ovat kelpoisia tutkimukseen | All |
| Näytteenottomenetelmä | Probability Sample |
| Hyväksyy terveelliset vapaaehtoiset | Joo |
| Kriteeri | Patients with acute tonsillitis: Inclusion Criteria: - Age between 15 and 40 years. - Subjective and objective signs of Acute Tonsillitis + presents of 2-4 Centor Criteria. - participation accept after verbal and written information. Exclusion Criteria: - Antibiotic treatment within the last month. - Other infection within the last month. - Inadequate tonsil swabs due to lack of cooperation. - Suspicion of peritonsillar abscess Control patients: Inclusion criteria: - Age between 15 and 40 years. - Participation accept after verbal and written information. Exclusion Criteria: - Antibiotic treatment within the last month. - Infection within the last month. - Tonsillectomy - More than 2 cases of acute tonsillitis within the last 12 months. |
Tulokset
Ensisijaiset tulosmittaukset
1. Procalcitonin [The participants will bee examined in family practice in 30 minuts, measurement results will be available after 3-4 month (average)]
Toissijaiset tulosmittaukset
1. Centor score [The participants will bee examined in family practice in 30 minuts, measurement results will be available after the consultation]
Muut lopputulokset
1. Cultured bacteria [Tonsillar surface swabs obtained at time of consultation. The consultation takes about 30 minuts and results will be analyzed approx. 1 time per week.]
