Five small bowel samples each of the duodenum, jejunum and ileum will be recruited treated.

Angiodysplasia

The samples will be spread and fixed using needles. The prototype RFA-SB ablation catheter will be applied by the PI as follows to each section of duodenum, jejunum and ileum.
The treating paddle of the prototype RFA-SB catheter will be pushed on the small bowel mucosa exerting the same pressure that would be applied endoscopically.
12 J/cm2 will be applied every time with a 20 second interval between applications to simulate clinical practice.
There will be two single applications to two separate specimen sites. There will be two double applications to two separate specimen sites. There will be two triple applications to two separate specimen sites. There will be two quadruple applications to two separate specimen sites.

Small bowel RFA treatment

Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter.

Study of the effect of RFA treatment on ex-vivo healthy small bowel mucosa including duodenum, jejunum, and ileum.

The Cleveland Clinic

Medtronic

Heart Disease

Aging

Amyloidosis

Aortic Valve Stenosis

During surgery, a basal LV septum biopsy will be collected for determination and quantification of interstitial deposits using specific staining which will be performed in a blind fashion

a basal LV septum biopsy

Hôpital Henri Mondor

Chu Fort de France

CHU Limoges

CHU LYON

Chu Rennes

Centre Cardiologique du Nord

CHU de Toulouse

Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

AMYLO-CARTESIAN Study :Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

All causes of death and cardiovascular hospitalization at 1 year after surgery

French Cardiology Society

Pfizer

Henri Mondor University Hospital

Myocardial Injury

St Antonius hospital

Myocardial Injury and Postoperative Complications

Postoperative Myocardial Injury and Non-cardiac Complications After Major Abdominal Surgery in Patients at Risk for Coronary Artery Disease

high sensitive troponin elevation at day 1, 3 or 7 after surgery

wound infection, pneumonia, anastomotic dehiscence, sepsis, respiratory insufficiency, bleeding, intestinal ischemia, death.

aortic valve stenosis/hypoxia

Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter.

Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

Myocardial Injury and Postoperative Complications

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