Transcatheter Aortic Valve Implantation Prosnosis and Complications

patients will be asked for a venous blood sample

venous blood withdrawl

Tel Aviv Medical Center

Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement

Tryptase Levels as a Marker of Mast Cell Activity and the Prognostic Implication in Patients Post Transcatheter Aortic Valve Replacement

Post procedural complications - major stroke, acute kidney injury, paravalvular regurgitation, permanent pacemaker implantation, coronary artery obstruction, heart block, vascular injury, pericardial hemorrhage

Only the principle investigator will have access to IPD

Tel-Aviv Sourasky Medical Center

The cohort will consist of about 55 female and 55 male individuals aged 30-65 years with mostly sedentary work (>6 hours/day) doing no or less physical activity (<30 minutes quick walking/day) who want to engage more in physical activity (at least 150 minutes of at least moderate intensity per week). The gain in workload will be objectified and quantified by performing a bicycle stress test at the beginning of the study and after 8 months of physical engagement.

Influence of 8 Months of Increased Physical Activity Workload on Osteoprotegerin and Endocan Levels

At least 150 minutes of moderate or 75 minutes of vigorous exercise per week. The "Recommendations for Adults From the American College of Sports Medicine and the American Heart Association" clearly define physical exercise intensity levels. The present study follows these recommendations. Consequently, moderate physical activity can be reached by e.g. quick walking, slow bicycling, slow swimming...; it is also possible to reach the expected workload by engaging in vigorous exercise (e.g. jogging/running, quick swimming, playing soccer/tennis...). The gain in performance will objectified by performing a bicycle stress test at the beginning and the end of the study.

Increased sports workload

Medical University of Vienna

IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers

Influence of Physical Activity on Promising Atherosclerosis Biomarkers

Osteoprotegerin and endocan levels will be measured at baseline, every 2 months of training and at the end of the observation after 8 months

Progerin, Myeloid-related peptide 8 and 14, Angiopoietin-like protein 2, Cathepsin S and K, Cystatin C and Placental growth levels will be measured at baseline, every 2 months of training and at the end of the observation after 8 months

Jeanette Strametz-Juranek

Prim.Univ.Prof.Dr.

Austrian Federal Ministry of Defence and Sports

General Anesthesia includes administration of a routine cardiac anesthetic as per institutional norms.

High Spinal and General Anesthesia includes a high dose intrathecal anesthetic administered prior to the induction of a standardized cardiac general anesthetic.

Aortic Stenosis

Spinal bupivacaine 0.75% in dextrose, 6 mls (45mg) and preservative free morphine 3 mcg/kg (to a maximum of 300 mcg).

High Spinal and General Anesthesia

St. Boniface General Hospital

The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery

The Effects of High Spinal Anesthesia on Hemodynamics, Stress Response, Renal Function and Post-operative Pain Control in Patients Undergoing Aortic Valve Replacement for Aortic Stenosis

aortic valve stenosis/protease

Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement

IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers

The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery

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