10 patients with normal echocardiogram studies and no history of ischaemic heart disease.
Patients to recieve CT-PET with fluciclatide, cardiac MRI scan, CT-coronary angiogram and echocardiogram.

Patients with moderate aortic stenosis. Patients are to recieve Cardiac MRI, CT-PET scan, echocardiography and CT-coronary angiogram scan at baseline.
They will undergo repeat cardiac MRI scan and echocardiogram at 12 - 24 months.

Patients with mild aortic stenosis. Patients are to recieve Cardiac MRI, CT-PET scan, echocardiography and CT-coronary angiogram scan at baseline.
They will undergo repeat cardiac MRI scan and echocardiogram at 12 - 24 months.

Patients with severe aortic stenosis. Patients are to recieve Cardiac MRI, CT-PET scan, echocardiography and CT-coronary angiogram scan at baseline.
They will undergo repeat cardiac MRI scan and echocardiogram at 12 - 24 months.

Patients with severe aortic stenosis proceeding to aortic valve replacement. Patients are to recieve Cardiac MRI, CT-PET scan, echocardiography and CT-coronary angiogram scan at baseline.
They will undergo a repeat CT-PET scan 3 months after the operation.
They will undergo repeat cardiac MRI scan and echocardiogram at 12 months after the operation.

Blood samples will be taken, and the serum frozen and stored for further analysis pending ethical approval.

Aortic Stenosis

Fibrosis

Neovascularization, Pathologic

Cardiac MRI scan with assessment of late gadolinium enhancement and T1 mapping.

Cardiac MRI scan

Computed Tomography / Positron Emission Tomography scan with 18F-fluciclatide tracer.

CT-PET scan

Echocardiogram

CT-coronary angiogram following CT-PET scan. Standard protocol.

CT-coronary angiogram scan

For AVR (already scheduled prior to enrollment)

Aortic Valve Replacement

University of Edinburgh

Angiogenesis and Fibrosis in Aortic Stenosis

The Identification of In Vivo Angiogenesis and Fibrosis in Aortic Stenosis Using Positron Emission Tomography

We will also recruit 10 patients with an angiographically documented chronic (>6 months) proximal coronary artery occlusion that has not been revascularised but has extensive collateral coronary blood flow.
We will perform CT-coronary angiogram, cardiac MRI scan and CT-PET scan.

These patients (n=15) will undergo Cardiac MRI, CT-PET scan and CT-coronary angiogram scan 2 weeks following their myocardial infarction.
They will undergo a second CT-PET scan 9 weeks following their myocardial infarction.
They will undergo a second cardiac MRI scan 6 - 12 months following their myocardial infarction.

aortic valve stenosis/tyrosine

Angiogenesis and Fibrosis in Aortic Stenosis

Angiogenesis and Fibrosis in Myocardial Infarction

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