In physical activity experimental group, trained study nurses will interview with patients,give health education,teach how to use and record the Activity meter.Professionals will calculate Metabolic Equivalent of Task(MET) with formula weekly.MET = (intensity level 9 points * time of each exercise (hours) * Number of times per week + moderate level 5 points * time per activity (hours) * number of times per week + low level 3 points * time per activity (hours) * number of times per week),investigators hope patients in the first month MET can reach (3.75-7.49 MET-h/ week), and reach moderate or more than moderate activity (>= 7.5-16.49 MET-h/ week) at the starting of second month for at least one year.

the non-physical activity group,investigators do not give them any physical interventions

Cancer Cervix Uterus

Precancerous Lesions

Smoking

Physical activity

Taipei Medical University

The Effect of Physical Activity and Abstain From Smoking on the Precancerous Lesion

The Effect of Physical Activity and Abstain From Smoking on the Regression of Precancerous Lesion.

To estimate the effect of moderate physical activity and abstain from smoking can strengthen the innate immune system,adaptive human immune system and can help regression of Cervical intraepithelial neoplasia among patients with cervical cancer.
Using a composite outcome measure consisting of questionnaire,blood counts,plasma and DNA.
blood counts :white blood cells,hemoglobin,red blood cells,platelets,Neutrophil,Lymphocyte,Monocyte,Eosinophil,Basophil,CD-4,CD-8,NK-cell,B-cell.
plasma:lL-1,IL-2,IL-4,IL-5,IL,6,LI-8,IL-10,IL-13,TNF-r

Patients undergo ablative or excisional therapy.
Quality of life is assessed at baseline, 3-5 days after ablation or excisional therapy, at 3 months, and then annually thereafter.
Patients are followed every 3-4 months until 2 consecutive normal Pap smears or colposcopic exams, every 6 months for 2 years, and then annually until 5 years after completion of study therapy.

Patients have topical imiquimod applied to the cervix for 6-10 hours twice weekly for a total of 5 doses. Within 3-4 weeks after the final application, patients undergo ablative or excisional therapy. Quality of life is assessed at baseline, after last dose of study drug, 3-5 days after ablation or excisional therapy, at 3 months, and then annually thereafter.
Patients are followed every 3-4 months until 2 consecutive normal Pap smears or colposcopic exams, every 6 months for 2 years, and then annually until 5 years after completion of study therapy.

Cervical Cancer

Precancerous Condition

imiquimod

Ablative or excisional therapy

CCOP - Mayo Clinic Scottsdale Oncology Program

Mayo Clinic

MBCCOP - Hawaii

CCOP - Carle Cancer Center

CCOP - Wichita

CCOP - Michigan Cancer Research Consortium

Mayo Clinic Cancer Center

CCOP - Sioux Community Cancer Consortium

Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia

Phase II Topical Immunomodulatory Therapy With Imiquimod for the Chemoprevention of Recurrent and High-Grade Cervical Intraepithelial Neoplasia (CIN)

cervical intraepithelial neoplasia/nikotiini

The Effect of Physical Activity and Abstain From Smoking on the Precancerous Lesion

Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia

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