Psyllium powder is used as the placebo. A member of the research staff will package and dispense L-alanine and placebo in similar containers. A standard measuring spoon will be provided to the subject for preparing the placebo solution. Subjects will mix the placebo in the beverage of their choice and consume this approximately 20 minutes before meals or snacks, in according with the dosing guidelines set for them by the dietitian.
Meal Placebo Breakfast * 1-2 scoops Snack * .5 - 1 scoop Lunch * 1-2 scoops Snack * .5 - 1 scoop Dinner * 1-2 scoops

L-alanine, USP (Spectrum® Chemicals and Laboratory Products, Gardena, CA) will be packaged and dispensed by one member of the research staff who will have no other role in the study. A one-month supply will be dispensed to the subjects.
Meal L-Alanine Breakfast * 1-2 scoops Snack * .5 - 1 scoop Lunch * 1-2 scoops Snack * .5 - 1 scoop Dinner * 1-2 scoops

Fructose Intolerance

Subjects will mix the placebo in the beverage of their choice and consume this approximately 20 minutes before meals or snacks, in according with the dosing guidelines set for them by the dietitian.

Placedo

Subjects will mix the alanine in the beverage of their choice and consume this approximately 20 minutes before meals or snacks, in according with the dosing guidelines set for them by the dietitian.

Alanine

Augusta University

Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance

Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance: a Double-blind, Randomized Study

Change in GI symptom score with alanine and placebo, when compared to the baseline

Estimated daily consumption of fructose during the alanine and placebo phases, when compared to the baseline using prospective food diaries

Changes in breath hydrogen and/or methane values with alanine and placebo when compared with to the baseline

Changes in SF-12 scores between and after baseline and placebo

Citrulline genration test before starting enteral nutrition
At ICU admission, a blood sample is collected (i) before and (ii) 90 minutes after N2-L-Alanyl-L-Glutamine administration

Enteral Nutrition

Intensive Care Unit

Biomarkers

20 gr of 10% N2-L-Alanyl-L-Glutamine, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes

N2-L-Alanyl-L-Glutamine (Substance)

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Feeding intolerance evaluated at day-3 of enteral nutrition Citrulline generation test: variation of citrullinemia/90 minutes

Feeding intolerance at day-3 of enteral nutrition Citrullinemia measured the first day just before initiation of enteral nutrition

Link between citrullinemia and cumulative amount of enteral nutrition administred during the first three days of ICU stay

Link between citrullinemia levels and occurrence of acute mesenteric ischemia and inhalation pneumopathy during the first week of enteral nutrition

Centre Hospitalier Universitaire de Besancon

A bolus of Dipeptiven (Glutamine-Alanine) administered intravenously over 30 minute (20 gramme of N2-L-Alanyl-L-Glutamine solution, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes).

l glutamine/ripuli

Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

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