neutropenia/kuume

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Viridans streptococci bacteraemia in children with fever and neutropenia: a case-control study of predisposing factors.

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Viridans streptococci (VS) are an increasing cause of bacteraemia in neutropenic patients with cancer. Case-control studies of predisposing factors for acquisition of this infection in children are not published. Between January 1989 and December 1999, 168 episodes of bacteraemia in 161 children

ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.

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BACKGROUND Cyclic neutropenia (CyN) is a rare hematological disease. Herein, a CyN girl, aged 3 years and 2 months, with recurrent fever and oral mucosal ulcer caused by neutrophil elastase (ELANE) gene mutation is reported. METHODS A 3 years and 2 months old girl presented with recurrent fever and

Evolving concepts in the management of patients with neutropenia and fever.

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Much has changed in the treatment of patients with fever and neutropenia, including the patterns of microbial flora and drug resistance and the drugs used. More patients now have indwelling central venous catheters, exposing them to new types of infections. This article reviews the recent treatment

Fluoroquinolones in children with fever and neutropenia: a systematic review of prospective trials.

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BACKGROUND There has been reluctance to use fluoroquinolones in children because of arthropathy in animal models; experience in pediatric fever and neutropenia (FN) has been limited. Our primary objective was to describe the effectiveness and safety of fluoroquinolones as empiric therapy for

Population pharmacokinetics of the piperacillin component of piperacillin/tazobactam in pediatric oncology patients with fever and neutropenia.

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BACKGROUND To describe the population pharmacokinetics of the piperacillin component of piperacillin/tazobactam. METHODS This pharmacokinetic study included 21 pediatric (age 3-10 years) patients receiving piperacillin/tazobactam to treat fever with neutropenia. Each patient contributed 1-3 blood

Neutropenia, fever, and infection in children with acute lymphocytic leukemia.

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In an attempt to determine the relationship between neutropenia (absolute granulocyte count less than 1,000/cu mm), infection, and disease status, 20 patients with acute lymphoblastic leukemia were observed for a total of 34 patient-years. Febrile episodes occurred with much greater frequency in

Dengue fever causing febrile neutropenia in children with acute lymphoblastic leukemia: an unknown entity.

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Dengue fever is endemic in many parts of the world but it has not been described as a cause of febrile neutropenia. We describe here clinical features, laboratory values and outcome in 10 children with acute lymphoblastic leukemia (ALL) and with dengue fever as a cause of febrile neutropenia. These

Clinical and laboratory parameter dynamics as markers of blood stream infections in pediatric oncology patients with fever and neutropenia.

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BACKGROUND Identifying markers associated with blood stream infection (BSI) in children with fever and neutropenia (FN) could lead to a substantial reduction in unnecessary treatment. OBJECTIVE The aim of this study was to determine the association between clinical/laboratory parameters and BSI in

Fever and neutropenia in pediatric hematopoietic stem cell transplant patients.

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The objective of this study was to identify patterns of fever and neutropenia in pediatric patients undergoing initial hospitalization for hematopoietic stem cell transplantation. A retrospective review of 75 HSCTs over a 4-year period at a single institution was performed, of which 68% were

Extreme neutropenia in glandular fever.

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Extreme neutropenia has very rarely been recorded as a complication of glandular fever. Two non-fatal cases, with mild secondary infections, are now reported. Extreme neutropenia may in fact be less rare in this disease than it appears to be, but serious illness as a result is exceedingly unusual.

Fever and neutropenia: still a challenge.

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Neutropenia is a double-edged sword. Fever may be the only manifestation of serious bacterial and fungal infection in neutropenic patients, and untreated occult infection can rapidly progress to septic shock and death.

Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia.

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We report a case of a severe hypersensitivity syndrome reaction to clopidogrel that resolved with dechallenge and recurred on rechallenge. The reaction included neutropenia, rash, fever, tachycardia, nausea, and vomiting. This presentation is very similar to the frequently reported hypersensitivity

Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever.

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It has been shown that Fas, Fas-L, TNF and TNFR-1 display high serum concentrations in subjects with sepsis. This suggests that these are potential severity markers. However, the serum concentration of these molecules in children with leukemia and suspected sepsis has to be established before

H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients.

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H-ficolin (Hakata antigen, ficolin-3) activates the lectin pathway of complement similar to mannose-binding lectin. However, its impact on susceptibility to infection is currently unknown. This study investigated whether the serum concentration of H-ficolin at diagnosis is associated with fever and

Frequency and clinical outcome of respiratory viral infections and mixed viral-bacterial infections in children with cancer, fever and neutropenia.

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BACKGROUND The role of respiratory viral infections (RVIs) as a cause of overall fever and neutropenia (FN) episodes in children with cancer has been less characterized than bacterial infections. We conducted a study aimed to determine the frequency of RVI in children with low compared with high

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