For each child, a toxicological screening will be carried out on the blood and urine for the research of proconvulsive molecules by conventional technique on the one hand and by gas chromatography coupled with a mass spectrograph on the other hand.
Intervention : Collection of blood and urine samples, and Clinical examination

Afebrile Seizure (Finding)

For each child, a toxicological screening will be carried out on the blood and urine for the research of proconvulsive molecules by conventional technique on the one hand and by gas chromatography coupled with a mass spectrograph on the other hand.

Collection of blood and urine samples

The other clinical data, any other biological samples or additional examinations are done under the opinion of the clinician or the neuropediatrics.

Clinical examination

Hôpital des enfants

Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure

Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study

Analyzed by systematic screening of a blood and urine sample.

It is the time between the admission to paediatric emergency unit and the detection of the first afebrile seizure's cause for paediatric patients

University Hospital, Toulouse

Transverse prevalence study. For each child, a toxicological screening will be carried out on the blood and urine for the research of proconvulsive molecules by conventional technique on the one hand and by gas chromatography coupled with a mass spectrograph on the other hand.

Bacterial Meningitis

glycerol by mouth (po) 1.5ml/kg max 25 ml/dose x 6 hourly x 8 doses
paracetamol PR 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7

Glycerol and paracetamol

paracetamol 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses

Paracetamol

paracetamol po 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses plus placebo suppository

po 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses plus placebo suppository

Placebo

35 mg/kg po first dose, then 20 mg/kg 6 hourly x 7 paracetamol
1.5 ml/kg max 25 ml/dose 6 hourly x 8 doses

Paracetamol and glycerol

glycerol 1.5 ml/kg /dose 6 hourly x 8 max dose = 25ml

Glycerol

College of Medicine, Queen Elizabeth Central Hospital

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis - A Prospective, Randomized, and Double-Blind Clinical Study Using a Two-by-Two Factorial Design

salicylate/seizures

Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

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