20 subjects do not receive any supplementation

20 subjects receive an Omega-Fatty-acid Nutratceutical

20 subjects receive an Omega-Fatty-acid Nutraceutical

20 subjects receive an Omega-Fatty-acid Nutraceutical + encapsulated fruit, vegetable and berry-juice concentrate

Healthy

no supplements given for 16 weeks, after 4 week washout of all supplements and dietetic products

control group

2 capsules of JP+® Omega/d for 16 weeks, after 4 week washout of all supplements and dietetic products

Omega2

4 capsules of JP+® Omega/d for 16 weeks, after 4 week washout of all supplements and dietetic products

Omega4

2 capsules of JP+® Omega/d plus 2 capsules each of an encapsulated fruit, vegetable and berry-juice concentrate (6 capsules) for 16 weeks, after 4 week washout of all supplements and dietetic products

Omega2+OGV

Institute of Pathophysiology and Immunology

Green Beat

Juice Plus+OMEGA Study

Bioavailability of Major Compounds of a Vegan Fatty-acid Nutraceutical and Its Effect on the Lipid Profile in Individuals With Suboptimal Serum-lipid Values

Omega 3 index in erythrocytes is a valid parameter to estimate bioavailability of omega 3 fatty acids

Lipid metabolism may change over the time in a positive manner due to micronutrient intervention

Absorption of ß-carotene, tocopherols, vitamin A and vitamin C after 8 and 16 weeks of supplementation, measured via HPLC, proven by a UV detector, analysed by means of an internal standard method, evaluated by paired t-test, and assessed via SPSS 22.0

Lamprecht Manfred PhD, PhD

Sponsor Investigator

Medical University of Graz

subjects are randomised into one of 4 intervention groups (control group (CG; consumption of 2 capsules of JP+® Omega Blend/d (Ω2); consumption of 4 capsules JP+® Omega Blend/d (Ω4); consumption of 2 capsules JP+® Omega Blend + Juice Plus+® fruit, vegetable and berry juice concentrate with 2 capsules each /d (Ω2+OGV)). Subjects allocated to Ω2 and Ω4 will receive the herbal fatty acid nutraceutical in the 4-month long study period (intervention phase), subjects allocated to Ω2+OGV will additionally receive the fruit, vegetable and berry juice concentrate. The control group will refrain from using any supplements over the course of this period and will maintain their usual eating habits.

Participants will drink 5ml of elderberry juice, diluted in 8oz of water, 3 times per day for three months.

Participants will drink 5ml of colored water, diluted in 8oz of water, 3 times per day for three months.

Mild Cognitive Impairment

Elderberry Juice

Placebo

University of Missouri Hospital

Effect of Elderberry Juice on Cognition and Inflammation in Patients With Mild Cognitive Impairment

Problem solving task for detecting non-memory impairments in MCI

Assesses memory, orientation, judgement and problem solving, community affairs, home/hobbies, personal care.

Screening for cognitive impairment sampling functions including arithmetic, memory and orientation.

Participants reproduce complicated line drawings.

Assesses functional performance in: visuospatial/executive, naming, memory, attention, language, abstraction, delayed recall, and orientation

sambucus cerulea/antioksidantti

Juice Plus+OMEGA Study

Effect of Elderberry Juice on Cognition and Inflammation in Patients With Mild Cognitive Impairment

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