Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis
Mots clés
Abstrait
La description
Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.
Rendez-vous
| Dernière vérification: | 08/31/2010 |
| Première soumission: | 08/22/2010 |
| Inscription estimée soumise: | 09/08/2010 |
| Première publication: | 09/09/2010 |
| Dernière mise à jour soumise: | 10/14/2010 |
| Dernière mise à jour publiée: | 10/17/2010 |
| Date de début réelle de l'étude: | 06/30/2010 |
| Date d'achèvement primaire estimée: | 08/31/2010 |
| Date estimée d'achèvement de l'étude: | 09/30/2010 |
Condition ou maladie
Intervention / traitement
Drug: drug: garlic extract, nystatin
Phase
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Other: drug: garlic extract, nystatin Drug: garlic extract 40mg/dl or nystatin suspension 100000 iu/ml tid for one month Patients had been clinically with denture stomatitis and confirmed by oral medicine specialist were selected for the study. Gender, age, medical history, erythema types, size, and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received garlic extract and second group used nystatin suspension for 1 month. Each patients was examined at the beginning of the therapy ,and then every 1 weeks up to 1 months . | Drug: drug: garlic extract, nystatin mouthwash |
Critère d'éligibilité
| Âges éligibles aux études | 40 Years À 40 Years |
| Sexes éligibles à l'étude | All |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: - 40 years of age and older - confirm of denture stomatitis by the oral medicine specialists Exclusion Criteria: - Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month - allergy to garlic and nystatin mouthwash - immunodeficiency - uncontrolled diabetes - those with garlic rich diet - inability in using mouthwash - loose and discolored dentures - psychologic disorder and alzheimer |
Résultat
Mesures des résultats primaires
1. reduction of diameter of erythematous lesion under denture [first week]
Mesures des résultats secondaires
1. complete relief of erythematous lesions [fourth week]
