Efficiency Study of Siwu Tang to Treat Brain Hypoperfusion Syndrome
Mots clés
Abstrait
La description
We designed a randomized, double-blinded controlled study, and a total of 80 patients with brain hypoperfusion syndrome should be finished assessment in two years. The 80 patients with hypoperfusion syndrome were divided into as follows:1) control group, receiving siwu tang placebo 3 g bid continuously two weeks except ordinary treatment; 2) treatment group, receiving siwu tang 3 g bid continuously two weeks except ordinary treatment. The patients were assessed before, and 4 weeks (weeks±3 days) and 12 weeks (12 weeks±3 days) after siwu tang treatment, respectively. Primary outcome measure was cerebral blood flow by using single photon emission computed tomography (SPECT); Second outcome measure included severity of dizziness by using visual analogue scale (VAS); cognitive function by using Mini-Mental Status (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR); quality of life by using barthel index (BI) and Functional Independent Measure (FIM).
We predict that siwu tang can improve cerebral blood flow, and clinical manifestation including dizziness, and cognition function and quality of life in patients with brain hypoperfusion syndrome .
Rendez-vous
| Dernière vérification: | 09/30/2010 |
| Première soumission: | 10/09/2010 |
| Inscription estimée soumise: | 10/13/2010 |
| Première publication: | 10/14/2010 |
| Dernière mise à jour soumise: | 10/13/2010 |
| Dernière mise à jour publiée: | 10/14/2010 |
| Date de début réelle de l'étude: | 06/30/2010 |
| Date d'achèvement primaire estimée: | 06/30/2012 |
| Date estimée d'achèvement de l'étude: | 10/31/2012 |
Condition ou maladie
Intervention / traitement
Drug: Siwu Tang
Phase
Critère d'éligibilité
| Âges éligibles aux études | 18 Years À 18 Years |
| Sexes éligibles à l'étude | All |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: - age between 18y/o to 80 y/o and had brain hypoperfusion syndrome such as dizziness - barthel index (BI) > 60。 - single photon emission computer tomography(SPECT) or MRI exam show hypoperfusion area Exclusion Criteria: - Patient had cancer or uremia,liver cirrhosis |
Résultat
Mesures des résultats primaires
1. cerebral blood flow [12 weeks after treatment]
Mesures des résultats secondaires
1. severity of dizziness [12 weeks after treatment]
2. cognitive function [12 weeks after treatment]
3. quality of life [12 weeks after treatment]
