Lactic Acidosis During and After Seizures
Mots clés
Abstrait
La description
Lactic acid is released from cells during seizures and elevates lactic acid levels in blood and saliva. The time course of this rise is unknown. If lactic acid rises within a few minutes of a seizure, than it might be feasible to develop lactic acid sensors to provide notification of a recent seizure. This could lead to better safety monitoring for people with epilepsy. This study was designed to utilize a commercially available lactic acid sensor (investigators have no connection with the sensor manufacturer and purchased the device at list price) to measure salivary lactic acid levels after a seizure during inpatient video-EEG epilepsy monitoring.
Rendez-vous
| Dernière vérification: | 04/30/2017 |
| Première soumission: | 03/27/2013 |
| Inscription estimée soumise: | 04/11/2013 |
| Première publication: | 04/15/2013 |
| Dernière mise à jour soumise: | 05/02/2017 |
| Dernière mise à jour publiée: | 05/04/2017 |
| Date des premiers résultats soumis: | 04/11/2016 |
| Date de la première soumission des résultats du CQ: | 05/02/2017 |
| Date des premiers résultats publiés: | 05/04/2017 |
| Date de début réelle de l'étude: | 06/30/2012 |
| Date d'achèvement primaire estimée: | 11/30/2014 |
| Date estimée d'achèvement de l'étude: | 11/30/2014 |
Condition ou maladie
Phase
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Epilepsy inpatients Patients with epilepsy recorded in an inpatient video-EEG monitoring unit after a seizure. |
Critère d'éligibilité
| Âges éligibles aux études | 18 Years À 18 Years |
| Sexes éligibles à l'étude | All |
| Méthode d'échantillonnage | Non-Probability Sample |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: 1. Age 18-75 inclusive. 2. History of at least one generalized tonic-clonic (grand mal) seizure prior to enrollment in the study. 3. Undergoing monitoring in the Stanford Epilepsy Monitoring Unit. Exclusion Criteria: 4. Not pregnant. 5. Inability to understand and sign the consent form. 6. No known history of mitochondrial disease or other metabolic disorders expected to affect blood lactate. 7. No known history of thrombophlebitis or excessive tendency to bleeding. Not on coumadin. Aspirin or anti-platelet agents are not an exclusion. 8. No known peripheral vascular disease affecting blood circulation to the fingers. 9. No painful peripheral neuropathy. 10. No Raynaud's disease or phenomenon. |
Résultat
Mesures des résultats primaires
1. Salivary Lactic Acid Levels With Seizures [Within 10 minutes of end of the seizure]
2. Capillary Lactic Acid Levels With Seizures [Within 10 minutes of end of the seizure]
3. Intravenous Lactic Acid Levels With Seizures [Within 10 minutes of end of the seizure]
