Understanding Childhood Infection, Inflammation and Allergy
Mots clés
Abstrait
La description
There is currently little understanding of the mechanisms by which respiratory infections can cause severe illness and death. The emergence of Influenza A subtype (H1N1) as a major cause of childhood severe illness in 2009 permitted further study of how this virus triggers severe disease, and how the inflammatory response to H1N1 differs from other infections. It is likely that host-mediated inflammatory processes triggered by the infecting agent contributes to severe illness. In addition, viral infection induces profound changes in the innate immune response to common bacterial pathogens, with increased bacterial colonisation of normally sterile lower airway. Thus both host and bacterial factors may contribute to lung damage in severe respiratory infection.
This study was initiated to identify the aetiology and immunopathologic mechanisms of childhood respiratory infection (Immunopathology of Respiratory Infection Study - IRIS), recruiting children with suspected respiratory infection or respiratory failure (and controls). This dataset will provide a unique resource for further study of disease mechanisms in children with a range of infections including H1N1/09 infection, Respiratory Syncytial Virus (RSV), Rhinovirus, other common respiratory viruses and severe bacterial infections.
Rendez-vous
| Dernière vérification: | 07/31/2019 |
| Première soumission: | 11/29/2009 |
| Inscription estimée soumise: | 11/29/2009 |
| Première publication: | 11/30/2009 |
| Dernière mise à jour soumise: | 08/06/2019 |
| Dernière mise à jour publiée: | 08/08/2019 |
| Date de début réelle de l'étude: | 07/19/2009 |
| Date d'achèvement primaire estimée: | 12/31/2019 |
| Date estimée d'achèvement de l'étude: | 12/31/2019 |
Condition ou maladie
Phase
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Infection, inflammation or allergy Children presenting via any means to St Mary's Hospital; this would include the A&E department, the general and infectious disease wards and the paediatric intensive care unit.
Children needing blood tests for any clinical reason Children who, in the clinical judgement of the doctor assessing them, have presented because of a condition consistent with an infectious, inflammatory or allergic process | |
| controls children who do not have an infectious, inflammatory or allergic condition, who anyway require blood tests for clinical reasons |
Critère d'éligibilité
| Sexes éligibles à l'étude | All |
| Méthode d'échantillonnage | Non-Probability Sample |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: - children presenting via any means to Hospital - children needing blood tests for any clinical reason - children who have presented because of a condition consistent with an infectious, inflammatory or allergic process Exclusion Criteria: - aged 17 or older - children re-presenting with the same condition - concern that the study is not fully understood by the parent or guardian |
Résultat
Mesures des résultats primaires
1. What are the bacterial and viral causes of acute illness in children presenting to a UK general hospital, tertiary paediatric infectious disease unit and paediatric intensive care unit? [3y]
2. What immunopathogenic mechanisms are involved in severe infection caused by specific bacterial and viral pathogens, and in inflammatory and allergic conditions? [5y]
