Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma
Mots clés
Abstrait
La description
Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.
Rendez-vous
Dernière vérification: | 07/31/2018 |
Première soumission: | 08/03/2018 |
Inscription estimée soumise: | 08/03/2018 |
Première publication: | 08/08/2018 |
Dernière mise à jour soumise: | 08/07/2018 |
Dernière mise à jour publiée: | 08/09/2018 |
Date de début réelle de l'étude: | 04/30/2016 |
Date d'achèvement primaire estimée: | 04/30/2017 |
Date estimée d'achèvement de l'étude: | 04/30/2017 |
Condition ou maladie
Phase
Groupes d'armes
Bras | Intervention / traitement |
---|---|
healthy individuals Orally and systemically healthy individuals who has no hypo-functional teeth, hyper-occlusion or occlusal trauma | |
periodontitis patients Systemically healthy individuals who has chronic periodontitis but no hypo-functional teeth, hyper-occlusion or occlusal trauma | |
healthy-occlusal trauma Orally and systemically healthy individuals who has occlusal trauma caused by bruxism | |
periodontitis-occlusal trauma Systemically healthy individuals who has both chronic periodontitis and occlusal trauma caused by bruxism |
Critère d'éligibilité
Âges éligibles aux études | 29 Years À 29 Years |
Sexes éligibles à l'étude | All |
Méthode d'échantillonnage | Probability Sample |
Accepte les bénévoles en santé | Oui |
Critères | Inclusion Criteria: - Systemical health - No drug use - No pregnancy or lactation For group 3 and 4; - Bruxism at least for 2 years - Occlusal trauma - Existence of at least 20 functioning teeth Exclusion Criteria: - Smoking - Pregnancy/lactation - Systemical disease - Drug use - Absence of at least 20 functioning teeth |
Résultat
Mesures des résultats primaires
1. Determination of certain bacterial species in subgingival dental plaque [A day after initial examination]
Mesures des résultats secondaires
1. hypoxic changes in gingiva and serum [One day after initial examination]