Effect of Limicol on (LDL)-Cholesterol Levels in Moderate Hypercholesterolaemia
Mots clés
Abstrait
La description
Cardiovascular disease (CVD), foremost among which ischemic heart disease and stroke, are the leading cause of mortality and morbidity in France. These diseases are multifactorial origin and even if it is not possible to act on risk markers such as age, sex, or heredity, risk factors like high cholesterol, smoking , hypertension, obesity, diabetes and physical inactivity, are the main target of prevention strategies.The dydlipidémies have a role in the formation of CVD in participating in the genesis of atherosclerosis. The cholesterol and LDL-cholesterol in particular is subject to oxidation process in plasma. The molecules of oxidized LDL-cholesterol, small and dense, easily penetrate the arterial endothelial wall and are greeted by macrophages. Following a succession of different processes including inflammation, atherosclerotic plaque is formed. The result is either an arteriopathy when the arterial lumen narrowing, or atherothrombosis in the event of plaque rupture. Given this pathophysiology, reduce blood lipids, including LDL-cholesterol and reducing oxidation and inflammation are interesting strategies in the context of cardiovascular prevention. Several scientific study showed that nutritional supplementation with some plant extracts such as artichokes, garlic, red yeast rice, or the sugar cane policosanol helps to reduce several cardiovascular risk factors including regulate concentrations of circulating lipids.
The objective of this study is to validate the effectiveness of Limicol, formulated with proven scientific data on the reduction of LDL-cholesterol in volunteers with moderate hypercholesterolaemia (LDL-cholesterol).
Rendez-vous
Dernière vérification: | 01/31/2012 |
Première soumission: | 06/06/2010 |
Inscription estimée soumise: | 06/06/2010 |
Première publication: | 06/07/2010 |
Dernière mise à jour soumise: | 02/20/2012 |
Dernière mise à jour publiée: | 02/21/2012 |
Date de début réelle de l'étude: | 04/30/2010 |
Date d'achèvement primaire estimée: | 10/31/2011 |
Date estimée d'achèvement de l'étude: | 12/31/2011 |
Condition ou maladie
Intervention / traitement
Dietary Supplement: Limicol (plant extract)
Phase
Critère d'éligibilité
Âges éligibles aux études | 18 Years À 18 Years |
Sexes éligibles à l'étude | All |
Accepte les bénévoles en santé | Oui |
Critères | Inclusion Criteria: - About 18 to 65 years (inclusive). - Subject has a stable weight for at least three months before the start of the study. - Subject able and willing to comply with the protocol and agreeing to give their consent in writing. - Subject affiliated with a social security scheme. - Subject willing to be included in the national register of volunteers who lend themselves to biomedical research. |
Résultat
Mesures des résultats primaires
1. LDL-cholesterol levels [4 months]
Mesures des résultats secondaires
1. Total cholesterol, HDL-cholesterol, triglycerides levels [4 months]