Effect of Proton Pump Inhibitors on Palpitations
Mots clés
Abstrait
La description
Methods Two hundred patients with palpitations and no clear cause for their symptoms will be randomized to receive either PPI or placebo for one month. At base line they will be investigated to rule out arrhythmia by documenting normal heart rate (less than 110 beat per minute) or ECG showing normal sinus rhythm or mild sinus tachycardia (Less than 110 per minute) during symptoms. Obvious causes such as anxiety due to a stressful event or organic causes such anemia or thyroid disorders should be also ruled out.
Patient who agree to participate in the study will be asked to sign an informed consent. A baseline questionnaire with symptoms will be filled. They will then be randomized for treatment with either PPI or placebo once at night time. After 10 days of treatment they will be contacted and questioned regarding their symptoms. The two groups will be compared to see if there is any improvement of symptoms with treatment.
Studying group The study will be under the umbrella of the JCC group. Primary investigators are Dr Munir Zaqqa and Dr Ismail Hamam
Support required Pharmaceutical company will be contacted to provide 120 packets with 30 tabs of PPI and if possible packets with similar matching placebo to support the study
Study criteria inclusion
1. Persons with palpitations and no clear cause who are above the age of 16 years and who consent to the study will be included
2. Clear causes that should be excluded are true arrhythmia such SVT or VT or frequent premature atrial or ventricular contractions or any organic cause such as thyroid disorder, anemia (hg less than 11 g/dl) and obvious anxiety disorder
3. Arrhythmia can be excluded by an ECG showing sinus rhythm or sinus tachycardia during episodes or measurement of heart rate by a reliable method during symptoms showing regular heart rate less than 120 beats per minute.
4. Patient will be randomized to either PPI or placebo to be taken one table at night time
5. Patients will be provided with 2 weeks supply but will be evaluated at 10 days to see if symptoms improved
6. The two groups will be compared using statistical methods to see if there is difference in improvement.
Expected harm:
PPI's are generally safe medications. Side effects are rare and generally mild. They include nausea, stomach pain, diarrhea, constipation or headache.
Very rarely allergic reaction can occur with hives, difficulty in breathing and swelling of the face and lips.
Benefit to the patient:
Patients randomized to either group may experience benefit due to the medication or even placebo use. There is no financial benefit of participating in the study. The result of the study will be used to help patient in the future with similar symptoms
Rendez-vous
| Dernière vérification: | 02/28/2018 |
| Première soumission: | 07/04/2016 |
| Inscription estimée soumise: | 07/06/2016 |
| Première publication: | 07/10/2016 |
| Dernière mise à jour soumise: | 03/08/2018 |
| Dernière mise à jour publiée: | 03/12/2018 |
| Date de début réelle de l'étude: | 09/30/2016 |
| Date d'achèvement primaire estimée: | 02/28/2018 |
| Date estimée d'achèvement de l'étude: | 02/28/2018 |
Condition ou maladie
Intervention / traitement
Drug: Active group
Drug: Placebo group
Phase
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Active Comparator: Active group Will receive Rabeprazole sodium (Proton pump inhibitor 20 mg once daily) | Drug: Active group WIll study effect of the medication on palpittions |
| Placebo Comparator: Placebo group Will receive Folic acid 5 mg once daily | Drug: Placebo group Placebo comparison to active treatment |
Critère d'éligibilité
| Âges éligibles aux études | 16 Years À 16 Years |
| Sexes éligibles à l'étude | All |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: 1. Persons with palpitations and no clear cause who are above the age of 16 years and who consent to the study will be included 2. Clear causes that should be excluded are true arrhythmia such SVT or VT or frequent premature atrial or ventricular contractions or any organic cause such as thyroid disorder, anemia (hg less than 11 g/dl) and obvious anxiety disorder 3. Arrhythmia can be excluded by an ECG showing sinus rhythm or sinus tachycardia during episodes or measurement of heart rate by a reliable method during symptoms showing regular heart rate less than 120 beats per minute. 4. Patient will be randomized to either PPI or placebo to be taken one table at night time 5. Patients will be provided with 2 weeks supply but will be evaluated at 10 days to see if symptoms improved 6. The two groups will be compared using statistical methods to see if there is difference in improvement. Exclusion Criteria: - Refusal to participate or sign consent form - Frequency of symptoms less than 2 times per week - Already taking PPI or H2 blocker |
Résultat
Mesures des résultats primaires
1. Improvement in Palpitations [2 weeks]
