Intervention With Legume Kernel Fibre in Healthy Subjects
Mots clés
Abstrait
La description
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower serum cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of legume kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
Seventy-eight healthy volunteers were enrolled. Seventy-six subjects (mean age of 24 years, 55 women and 21 men) completed the double-blind, randomized crossover trial. After two weeks run-in period, half of the volunteers consumed 25 g of legume fibres (Boregine, TypTop or Soy fibre) every day, and the other half received a reference fibre product (citrus fibre, Herbacel AQ Plus) for a period of two weeks. After two weeks wash-out the intervention changed between the groups.
At the end of each period a quantitative stool and urine collection took place and fasting blood samples were drawn.
Rendez-vous
| Dernière vérification: | 11/30/2009 |
| Première soumission: | 12/16/2009 |
| Inscription estimée soumise: | 12/17/2009 |
| Première publication: | 12/20/2009 |
| Dernière mise à jour soumise: | 11/04/2012 |
| Dernière mise à jour publiée: | 11/05/2012 |
| Date de début réelle de l'étude: | 06/30/2007 |
| Date d'achèvement primaire estimée: | 11/30/2007 |
| Date estimée d'achèvement de l'étude: | 11/30/2007 |
Condition ou maladie
Intervention / traitement
Dietary Supplement: pure fibre-product
Dietary Supplement: reference fibre
Phase
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Experimental: TypTop Lupinus albus Typ Top (lupin kernel fibre, dietary fibre content: 83%) | |
| Experimental: Soy fibre Glycine max Hefeng (soy fibre; dietary fibre content: 77%) | |
| Experimental: Boregine Lupinus angustifolius Boregine (lupin kernel fibre, dietary fibre content: 87%) |
Critère d'éligibilité
| Âges éligibles aux études | 20 Years À 20 Years |
| Sexes éligibles à l'étude | All |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: - age 20-45 years - healthy subjects Exclusion Criteria: - intake of pharmaceuticals and nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic diseases |
Résultat
Mesures des résultats primaires
1. Changes of serum lipids (cholesterol metabolism) [after 2, 4 and 8 weeks]
Mesures des résultats secondaires
1. Changes of general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion [after 2, 4 and 8 weeks]
